GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000197
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Linaria vulgaris - bilateral
Trait State in Taxon B
Linaria vulgaris - radial
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
common toadflax
Synonyms
common toadflax; Linaria vulgaris Mill.
Rank
species
Lineage
Show more ... a; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Linaria
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
common toadflax
Synonyms
common toadflax; Linaria vulgaris Mill.
Rank
species
Lineage
Show more ... a; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Linaria
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
UniProtKB
Antirrhinum majus
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
Stable methylation
Experimental Evidence
Authors
Cubas P; Vincent C; Coen E
Abstract
Although there have been many molecular studies of morphological mutants generated in the laboratory, it is unclear how these are related to mutants in natural populations, where the constraints of natural selection and breeding structure are quite different. Here we characterize a naturally occurring mutant of Linaria vulgaris, originally described more than 250 years ago by Linnaeus, in which the fundamental symmetry of the flower is changed from bilateral to radial. We show that the mutant carries a defect in Lcyc, a homologue of the cycloidea gene which controls dorsoventral asymmetry in Antirrhinum. The Lcyc gene is extensively methylated and transcriptionally silent in the mutant. This modification is heritable and co-segregates with the mutant phenotype. Occasionally the mutant reverts phenotypically during somatic development, correlating with demethylation of Lcyc and restoration of gene expression. It is surprising that the first natural morphological mutant to be characterized should trace to methylation, given the rarity of this mutational mechanism in the laboratory. This indicates that epigenetic mutations may play a more significant role in evolution than has hitherto been suspected.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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