GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001974
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Peromyscus maniculatus - Nebraska Sand Hills - dark coat
Trait State in Taxon B
Peromyscus maniculatus - Nebraska Sand Hills - light coat
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
North American deer mouse
Synonyms
North American deer mouse; Peromyscus maniculatus (Wagner, 1845); MSB Mamm 74965; MSB:collector:Mamm:74965; Peromyscus maniculatis
Rank
species
Lineage
Show more ... eostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Peromyscus maniculatus - Nebraska Sand Hills
Taxon B
Common Name
North American deer mouse
Synonyms
North American deer mouse; Peromyscus maniculatus (Wagner, 1845); MSB Mamm 74965; MSB:collector:Mamm:74965; Peromyscus maniculatis
Rank
species
Lineage
Show more ... eostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Neotominae; Peromyscus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Peromyscus maniculatus - Nebraska Sand Hills
GENOTYPIC CHANGE
Mutation #1
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
several candidate mutations (SNPs and deletion of Ser in exon 2) associated with tail stripe coloration
Experimental Evidence
Authors
Linnen CR; Poh YP; Peterson BK; Barrett RD; Larson JG; Jensen JD; Hoekstra HE
Abstract
The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.
Mutation #2
Presumptive Null
No
Molecular Type
Aberration Type
SNP
Molecular Details of the Mutation
several candidate SNPs associated with dorso-ventral boundary of coloration
Experimental Evidence
Authors
Linnen CR; Poh YP; Peterson BK; Barrett RD; Larson JG; Jensen JD; Hoekstra HE
Abstract
The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.
Mutation #3
Presumptive Null
No
Molecular Type
Aberration Type
SNP
Molecular Details of the Mutation
several candidate SNPs associated with dorsal brightness
Experimental Evidence
Authors
Linnen CR; Poh YP; Peterson BK; Barrett RD; Larson JG; Jensen JD; Hoekstra HE
Abstract
The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.
Mutation #4
Presumptive Null
No
Molecular Type
Aberration Type
SNP
Molecular Details of the Mutation
one candidate SNP associated with dorsal hue
Experimental Evidence
Authors
Linnen CR; Poh YP; Peterson BK; Barrett RD; Larson JG; Jensen JD; Hoekstra HE
Abstract
The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.
Mutation #5
Presumptive Null
No
Molecular Type
Aberration Type
Deletion Size
1-9 bp
Molecular Details of the Mutation
Deletion in exon 2 leading to a Ser deletion causes causes lighter coat colour via changes in protein binding properties ; as demonstrated by transgenic mice with either Peromyscus alleles (Barrett et al. 2019)
Experimental Evidence
Authors
Linnen CR; Poh YP; Peterson BK; Barrett RD; Larson JG; Jensen JD; Hoekstra HE
Abstract
The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic change. Using plasticine models in the field, we show that the light coat color of deer mice that recently colonized the light-colored soil of the Nebraska Sand Hills provides a strong selective advantage against visually hunting predators. Color variation in an admixed population suggests that this light Sand Hills phenotype is composed of multiple traits. We identified distinct regions within the Agouti locus associated with each color trait and found that only haplotypes associated with light trait values have evidence of selection. Thus, local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
2
COMMENTS
@SeveralMutationsWithEffect @Fitness
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