GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001978
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
light-brown and white individuals
Trait State in Taxon B
black and dark-brown coat colors ; Magaheem and Sofor
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
Arabian camel
Synonyms
Arabian camel; camel; dromedaries; dromedary; dromedary camel; one-humped camel; Camelus dromedarius Linnaeus, 1758
Rank
species
Lineage
Show more ... athostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; Camelidae; Camelus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
Arabian camel
Synonyms
Arabian camel; camel; dromedaries; dromedary; dromedary camel; one-humped camel; Camelus dromedarius Linnaeus, 1758
Rank
species
Lineage
Show more ... athostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Cetartiodactyla; Tylopoda; Camelidae; Camelus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
1-9 bp
Molecular Details of the Mutation
1-bp deletion at position 23 resulting in frameshift
Experimental Evidence
Authors
Almathen F; Elbir H; Bahbahani H; Mwacharo J; Hanotte O
Abstract
Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes. Using 91 animals from 10 Arabian camel populations, that included the 4 predominant coat color phenotypes observed in the dromedary (light brown, dark brown, black, and white), we investigated the effects of the MC1R and ASIP sequence variants and identified candidate polymorphisms associated with coat color variation. In particular, we identified a single nucleotide polymorphism (SNP), found in the coding region of MC1R (901C/T), linked to the white coat color, whereas a 1-bp deletion (23delT/T) and a SNP (25G/A) in exon 2 of ASIP are associated with both black and dark-brown coat colors. Our results also indicate support that the light-brown coat color is likely the ancestral coat color for the dromedary. These sequence variations at the MC1R and ASIP genes represent the first documented evidence of candidate polymorphisms associated with Mendelian traits in the dromedary.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
https://omia.org/OMIA000201/9838/
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