GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001985
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila melanogaster
Trait State in Taxon B
Drosophila melanogaster - hypersensitive to paraquat - CA1 allele
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Sod1
Synonyms
Cu; 24492; CG11793; cSod; cSOD; Cu-Zn SOD; Cu/Zn sod; Cu/Zn SOD; Cu/Zn superoxide dismutase; Cu/ZnSOD; CuSOD; CuZn SOD; CuZn-SOD; CuZn-SOD1; CuZnSOD; Cu[2+]/Zn[2+]SOD; Dmel\CG11793; dsod; dSOD1; G; l(3)108; l(3)68Af'; l(3)G; Mn SOD; sod; Sod; SOD; Sod-1; SOD-1; sod1; SOD1; SODC_DROME; To; To-1; Zn Sod; Zn SOD; Zn-SOD; ZnSod
Sequence Similarities
Belongs to the Cu-Zn superoxide dismutase family.
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Insertion Size
100-999 bp
Molecular Details of the Mutation
Insertion of a 0.68kb truncated P-element 47bp downstream of the transcription start site.
Experimental Evidence
Authors
Vontas JG; Tsakas SC; Loukas M; Hemingway J
Abstract
Different types of mutations and DNA-damage profiles induced by near-UV radiation and the superoxide anion (O2-.) indicate separate lesions and (or) mechanisms of mutagenesis. Despite a wealth of data, it is still unclear whether variations in the activity levels of antioxidant enzymes naturally present in suboptimal concentrations are among the underlying causes of the increase of near UV radiation genotoxicity. We incorporated a low-activity allele of copper-zinc superoxide dismutase (CuZnSOD), recovered from natural populations of Drosophila melanogaster, into standard marked strains and employed a somatic mutation and recombination test (SMART) to compare paraquat and near UV radiation genotoxicity in these strains. Our results show that, although the low-activity CuZnSOD allele of D. melanogaster confers hypersensitivity to paraquat, the near UV radiation damage was not affected.
Additional References
EXTERNAL LINKS
COMMENTS
@TE - http://flybase.org/reports/FBal0282693
YOUR FEEDBACK is welcome!