GEPHE SUMMARY Print
Gephebase Gene
alcohol dehydrogenase (Adh)
Entry Status
Published
GepheID
GP00001988
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Physiology
Trait
Xenobiotic resistance (alcohol)
Trait State in Taxon A
Drosophila melanogaster - slow allele - lower enzyme activity
Trait State in Taxon B
Drosophila melanogaster - temperature-sensitive allele - high enzyme activity at high temperature and low enzyme activity at low temperature
Ancestral State
Taxon A
Taxonomic Status
Intraspecific
Taxon A
Latin Name
Drosophila melanogaster
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
Parent
melanogaster subgroup () - (Rank: species subgroup)
NCBI Taxonomy ID
7227
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Drosophila melanogaster
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
Parent
melanogaster subgroup () - (Rank: species subgroup)
NCBI Taxonomy ID
7227
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Adh
Synonyms
adh; ADH; Adh3; BG:DS01486.8; CG32954; CG3481; dADH; DM-ADH; DmADH; Dmel\CG3481; Dreg-1; Reg-1; T16
String
7227.FBpp0100048
Sequence Similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
GO - Molecular Function
GO:0042803 : protein homodimerization activity ... show more
GO - Biological Process
GO:0006117 : acetaldehyde metabolic process ... show more
GO - Cellular Component
GO:0005829 : cytosol ... show more
UniProtKB
Drosophila melanogaster
P00334
GenebankID or UniProtKB
M22210
Presumptive Null
No
Molecular Type
Coding
Aberration Type
Unknown
Molecular Details of the Mutation
Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.
Experimental Evidence
Linkage Mapping
Main Reference
Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila. (1974)
Authors
Vigue C; Sofer W
Abstract
-
Additional References
RELATED GEPHE
Related Genes
19 (Acetylcholinesterase (Ace-2), Aldehyde dehydrogenase (Aldh), CG11699, Cyp12d1, Cyp28d1, Cyp28d1-Cyp28d2, cyp6d2, cyp6g1, glutamate-gated chloride channel (GluCl), GSS (glutathione synthetase), GSTE1-E10 cluster, kin of irre (kire), para (kdr), PHGPx, resistance to dieldrin, RnrS, SOD1, Ugt86Dd, CHKov1)
Related Haplotypes
4
EXTERNAL LINKS
COMMENTS
http://flybase.org/reports/FBal0000346
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