GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002002
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila melanogaster - allele with repeat (Thr-Gly)17
Trait State in Taxon B
Drosophila melanogaster - allele with repeat (Thr-Gly)20
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
per
Synonyms
CG2647; Clk; clk-6; Dmel\CG2647; dmper; dper; dPER; EG:155E2.4; mel_per; Per; PER; Per-2
String
Sequence Similarities
-
GO - Molecular Function
GO:0042802 : identical protein binding
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GO - Biological Process
GO:0009416 : response to light stimulus
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GO - Cellular Component
GO:0005737 : cytoplasm
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UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Presumptive Null
Molecular Type
Aberration Type
Indel Size
10-99 bp
Molecular Details of the Mutation
repeat (Thr-Gly) either 17 times or 20 times within the protein coding sequence
Experimental Evidence
Authors
Sawyer LA; Hennessy JM; Peixoto AA; Rosato E; Parkinson H; Costa R; Kyriacou CP
Abstract
The threonine-glycine (Thr-Gly) encoding repeat within the clock gene period of Drosophila melanogaster is polymorphic in length. The two major variants (Thr-Gly)17 and (Thr-Gly)20 are distributed as a highly significant latitudinal cline in Europe and North Africa. Thr-Gly length variation from both wild-caught and transgenic individuals is related to the flies' ability to maintain a circadian period at different temperatures. This phenomenon provides a selective explanation for the geographical distribution of Thr-Gly lengths and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
EXTERNAL LINKS
COMMENTS
http://flybase.org/reports/FBal0082362 - http://flybase.org/reports/FBal0082363 - http://flybase.org/reports/FBal0082364 - http://flybase.org/reports/FBal0082365 - http://flybase.org/reports/FBal0082366
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