GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002022
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
dark posterior male abdomen
Trait State in Taxon B
light posterior male abdomen
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Drosophila yakuba Burla, 1954
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
pdm3
Synonyms
BcDNA:AT16994; CG11641; CG14755; CG42698; Dmel\CG42698; Pdm3; Dmel_CG42698
String
-
Sequence Similarities
Belongs to the POU transcription factor family.
GO - Cellular Component
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
change in a cis-regulatory region - exact causing mutation(s) unknown - increased pdm3 abdominal expression associated with lighter color
Experimental Evidence
Authors
Liu Y; Ramos-Womack M; Han C; Reilly P; Brackett KL; Rogers W; Williams TM; Andolfatto P; et al. ... show more
Abstract
Hox genes pattern the anterior-posterior axis of animals and are posited to drive animal body plan evolution, yet their precise role in evolution has been difficult to determine. Here, we identified evolutionary modifications in the Hox gene Abd-B that dramatically altered its expression along the body plan of Drosophila santomea. Abd-B is required for pigmentation in Drosophila yakuba, the sister species of D. santomea, and changes to Abd-B expression would be predicted to make large contributions to the loss of body pigmentation in D. santomea. However, manipulating Abd-B expression in current-day D. santomea does not affect pigmentation. We attribute this epistatic interaction to four other genes within the D. santomea pigmentation network, three of which have evolved expression patterns that do not respond to Abd-B. Our results demonstrate how body plans may evolve through small evolutionary steps distributed throughout Hox-regulated networks. Polygenicity and epistasis may hinder efforts to identify genes and mechanisms underlying macroevolutionary traits.

Copyright © 2019 Elsevier Ltd. All rights reserved.
Additional References
RELATED GEPHE
Related Haplotypes
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