GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002038
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
wild-type - asymmetric caudal fin
Trait State in Taxon B
symmetrical caudal skeleton
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
Japanese medaka
Synonyms
Poecilia latipes; Japanese medaka; Japanese rice fish; medaka; Oryzias latipes (Temminck & Schlegel, 1846); Poecilia latipes Temminck & Schlegel, 1846; Orizias latipes
Rank
species
Lineage
Show more ... ha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyoidei; Adrianichthyidae; Oryziinae; Oryzias
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
Japanese medaka
Synonyms
Poecilia latipes; Japanese medaka; Japanese rice fish; medaka; Oryzias latipes (Temminck & Schlegel, 1846); Poecilia latipes Temminck & Schlegel, 1846; Orizias latipes
Rank
species
Lineage
Show more ... ha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyoidei; Adrianichthyidae; Oryziinae; Oryzias
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Insertion Size
-
Molecular Details of the Mutation
insertion of a large transposon (Albatross) into the enhancer region of the zic1 and zic4 genes. Both genes are expressed by a bi-directional promoter. This transposon insertion disrupts the expression of the transcription factors in the dorsal somites and this causes the centralised trunk phenotype. Inoue et al. 2017show that the transposon “Albatross” is actually way larger and the authors call it “Teratorn”. Teratorn is 180-kb long and appears to originate from the fusion of a DNA transposon and a herpesvirus.
Experimental Evidence
Authors
Moriyama Y; Kawanishi T; Nakamura R; Tsukahara T; Sumiyama K; Suster ML; Kawakami K; Toyoda A; et al. ... show more
Abstract
Teleosts have an asymmetrical caudal fin skeleton formed by the upward bending of the caudal-most portion of the body axis, the ural region. This homocercal type of caudal fin ensures powerful and complex locomotion and is regarded as one of the most important innovations for teleosts during adaptive radiation in an aquatic environment. However, the mechanisms that create asymmetric caudal fin remain largely unknown. The spontaneous medaka (teleost fish) mutant, Double anal fin (Da), exhibits a unique symmetrical caudal skeleton that resembles the diphycercal type seen in Polypterus and Coelacanth. We performed a detailed analysis of the Da mutant to obtain molecular insight into caudal fin morphogenesis. We first demonstrate that a large transposon, inserted into the enhancer region of the zic1 and zic4 genes (zic1/zic4) in Da, is associated with the mesoderm-specific loss of their transcription. We then show that zic1/zic4 are strongly expressed in the dorsal part of the ural mesenchyme and thereby induce asymmetric caudal fin development in wild-type embryos, whereas their expression is lost in Da. Comparative analysis further indicates that the dorsal mesoderm expression of zic1/zic4 is conserved in teleosts, highlighting the crucial role of zic1/zic4 in caudal fin morphogenesis.

Copyright © 2012 Elsevier Ltd. All rights reserved.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
@TE - The mutant was isolated by chance from a wild population in the 1960s.
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