GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00002039
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
wild and domesticated canari
Trait State in Taxon B
canari - urucum breed - bright red bills and legs
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
common canary
Synonyms
Serinus canarius; common canary; canary; Serinus canaria (Linnaeus, 1758)
Rank
species
Lineage
Show more ... ; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae; Carduelinae; Serinus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
common canary
Synonyms
Serinus canarius; common canary; canary; Serinus canaria (Linnaeus, 1758)
Rank
species
Lineage
Show more ... ; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae; Carduelinae; Serinus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
urucum canari breed
GENOTYPIC CHANGE
Presumptive Null
Yes
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
point mutation at nucleotide position 837,806 that is predicted to be a nonsynonymous mutation in the exon 9 of the BCO2 gene. This variant results in the substitution of a histidine for an arginine at residue 413 of the protein (R413H) . In silico analysis suggests that the R413H could cause structural distortion of the protein and lead to a possible loss of activity. In vitro assays with the urucum BCO2 variant show that the enzyme activity is lost.
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid His Arg 413
Authors
Gazda Malgorzata A.; Toomey Matthew B.; Araujo Pedro M.; Lopes Ricardo J.; Afonso Sandra; Myers Connie A.; Serres Kyla; Kiser Phylip D.; et al. ... show more
Abstract
-
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
Paper is on BioRxiv - https://www.biorxiv.org/content/10.1101/762112v1 . Allele-specific expression in the shared cellular environment of individuals heterozygous for the urucum and wild-type alleles show same expression levels of both alleles, suggesting that there is no cis-regulatory mutations in the urucum breed.
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