GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002053
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Low physiological ability to survive in freshwater DHA free diets
Trait State in Taxon B
High physiological ability to survive in freshwater DHA free diets
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
ninespine stickleback
Synonyms
Gasterosteus pungitius; ninespine stickleback; Gasterosteus pungitius Linnaeus, 1758; Pungitius pungitius (Linnaeus, 1758)
Rank
species
Lineage
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hala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Pungitius
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B #1
Latin Name
Common Name
Sakhalin sticlkeback
Synonyms
Gasterosteus tymensis; Sakhalin sticlkeback; Gasterosteus tymensis Nikolskii, 1889; Pungitius tymensis (Nikolskii, 1889)
Rank
species
Lineage
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hala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Pungitius
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
Taxon B #2
Latin Name
Common Name
-
Synonyms
Amur stickleback; Pygosteus kaibarae; Pungitius kaibarae (Tanaka, 1915); Pygosteus kaibarae Tanaka, 1915
Rank
species
Lineage
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hala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Pungitius
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
fads2
Synonyms
Fadsd6; DRD5/D6; wu:fb64c04; wu:fb69e08; zgc:112502; fadsd6
String
Sequence Similarities
Belongs to the fatty acid desaturase type 1 family.
GO - Molecular Function
GO - Biological Process
GO:0006636 : unsaturated fatty acid biosynthetic process
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GO - Cellular Component
GO:0016021 : integral component of membrane
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UniProtKB
Danio rerio
Danio rerio
Presumptive Null
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
higher number of copies of Fads2.
Experimental Evidence
Main Reference
Authors
Ishikawa A; Kabeya N; Ikeya K; Kakioka R; Cech JN; Osada N; Leal MC; Inoue J; et al.
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Abstract
Colonization of new ecological niches has triggered large adaptive radiations. Although some lineages have made use of such opportunities, not all do so. The factors causing this variation among lineages are largely unknown. Here, we show that deficiency in docosahexaenoic acid (DHA), an essential ω-3 fatty acid, can constrain freshwater colonization by marine fishes. Our genomic analyses revealed multiple independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages that subsequently colonized and radiated in freshwater habitats, but not in close relatives that failed to colonize. Transgenic manipulation of Fads2 in marine stickleback increased their ability to synthesize DHA and survive on DHA-deficient diets. Multiple freshwater ray-finned fishes also show a convergent increase in Fads2 copies, indicating its key role in freshwater colonization.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Both P. tymensis and P. kaibarae are entirely freshwater species. Pungitius sinensis; which inhabits both freshwater and brackish environments; has Fads2 copy numbers intermediate between those of P. pungitius and freshwater nine-spined sticklebacks
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