GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Draft
GepheID
GP00002057
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Pectinophora gossypiella - Bt-Cry2Ab susceptible
Trait State in Taxon B
Pectinophora gossypiella - Bt-Cry2Ab resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ... Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ... Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
ABCA2
Synonyms
-
String
-
Sequence Similarities
-
GO - Biological Process
-
UniProtKB
Helicoverpa armigera
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
loss of exon 6 caused by alternative splicing
Experimental Evidence
Authors
Mathew LG; Ponnuraj J; Mallappa B; Chowdary LR; Zhang J; Tay WT; Walsh TK; Gordon KHJ; et al. ... show more
Abstract
Evolution of pest resistance threatens the benefits of genetically engineered crops that produce Bacillus thuringiensis (Bt) insecticidal proteins. Strategies intended to delay pest resistance are most effective when implemented proactively. Accordingly, researchers have selected for and analyzed resistance to Bt toxins in many laboratory strains of pests before resistance evolves in the field, but the utility of this approach depends on the largely untested assumption that laboratory- and field-selected resistance to Bt toxins are similar. Here we compared the genetic basis of resistance to Bt toxin Cry2Ab, which is widely deployed in transgenic crops, between laboratory- and field-selected populations of the pink bollworm (Pectinophora gossypiella), a global pest of cotton. We discovered that resistance to Cry2Ab is associated with mutations disrupting the same ATP-binding cassette transporter gene (PgABCA2) in a laboratory-selected strain from Arizona, USA, and in field-selected populations from India. The most common mutation, loss of exon 6 caused by alternative splicing, occurred in resistant larvae from both locations. Together with previous data, the results imply that mutations in the same gene confer Bt resistance in laboratory- and field-selected strains and suggest that focusing on ABCA2 genes may help to accelerate progress in monitoring and managing resistance to Cry2Ab.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
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