GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002063
Main curator
Courtier
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait State in Taxon A
D. serrata - relatively desiccation resistant and produces relatively large amounts of mbCHCs
Trait State in Taxon B
D. birchii - desiccation sensitive and produces very low amounts of mbCHCs
Trait #2
Trait Category
Trait State in Taxon A
D. serrata - relatively desiccation resistant and produces relatively large amounts of mbCHCs
Trait State in Taxon B
D. birchii - desiccation sensitive and produces very low amounts of mbCHCs
Ancestral State
Unknown
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Drosophila serrata Malloch, 1927
Rank
species
Lineage
Show more ... eura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; montium subgroup; Drosophila serrata species complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
Drosophila birchii Dobzhansky & Mather, 1961
Rank
species
Lineage
Show more ... eura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; montium subgroup; Drosophila serrata species complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
FASN3
Synonyms
CG17374; Dmel\CG17374; DM_7289423; FAS; FASN[CG17374]; FAS[CG17374]; Dmel_CG17374
Sequence Similarities
-
GO - Cellular Component
-
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
No expression of the gene in D. birchii. The coding region of the D. birchii gene is intact. Cis-regulatory region tested in reporter assays in D. melanogaster - exact causing mutation(s) unknown. RNAi against mFAS/CG17354 in D. serrata recapitylates the D. birchii phenotype.
Experimental Evidence
Authors
Chung H; Loehlin DW; Dufour HD; Vaccarro K; Millar JG; Carroll SB
Abstract
Evolutionary changes in traits involved in both ecological divergence and mate choice may produce reproductive isolation and speciation. However, there are few examples of such dual traits, and the genetic and molecular bases of their evolution have not been identified. We show that methyl-branched cuticular hydrocarbons (mbCHCs) are a dual trait that affects both desiccation resistance and mate choice in Drosophila serrata. We identify a fatty acid synthase mFAS (CG3524) responsible for mbCHC production in Drosophila and find that expression of mFAS is undetectable in oenocytes (cells that produce CHCs) of a closely related, desiccation-sensitive species, D. birchii, due in part to multiple changes in cis-regulatory sequences of mFAS. We suggest that ecologically influenced changes in the production of mbCHCs have contributed to reproductive isolation between the two species.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
Direction of change unknown but since this is a full loss of expression in oenocytes we can hypothesize that D. birchii displays the derived trait.
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