GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002102
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Culex pipiens - sensitive
Trait State in Taxon B
Culex pipiens fasciatus - resistant - allele cpm1BP
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
-
Synonyms
-
String
-
Sequence Similarities
-
GO - Molecular Function
-
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsense
Molecular Details of the Mutation
Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin.
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Gln STP 396
Authors
Darboux I; Charles JF; Pauchet Y; Warot S; Pauron D
Abstract
The binary toxin is the major active component of Bacillus sphaericus, a microbial larvicide used for controlling some vector mosquito-borne diseases. B. sphaericus resistance has been reported in many part of the world, leading to a growing concern for the usefulness of this environmental friendly insecticide. Here we characterize a novel mechanism of resistance to the binary toxin in a natural population of the West Nile virus vector, Culex pipiens. We show that the insertion of a transposable element-like DNA into the coding sequence of the midgut toxin receptor induces a new mRNA splicing event, unmasking cryptic donor and acceptor sites located in the host gene. The creation of the new intron causes the expression of an altered membrane protein, which is incapable of interacting with the toxin, thus providing the host mosquito with an advantageous phenotype. As a large portion of insect genomes is composed of transposable elements or transposable elements-related sequences, this new mechanism may be of general importance to appreciate their significance as potent agents for insect resistance to the microbial insecticides.
Additional References
RELATED GEPHE
Related Haplotypes
1
EXTERNAL LINKS
COMMENTS
YOUR FEEDBACK is welcome!