GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002121
Main curator
Santos
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Yellow (head and wings) and green (body) feathers
Trait State in Taxon B
White (head and wings) and blue (body) feathers
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
budgerigar
Synonyms
budgerigar
Rank
species
Lineage
Show more ... pnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Psittaciformes; Psittaculidae; Melopsittacus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
wild budgerigar
Taxon B
Common Name
budgerigar
Synonyms
budgerigar
Rank
species
Lineage
Show more ... pnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Psittaciformes; Psittaculidae; Melopsittacus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
domesticated breed
GENOTYPIC CHANGE
Generic Gene Name
PKS15
Synonyms
1; RLOC_00005487
String
-
Sequence Similarities
-
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
Lonchura striata domestica
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
-
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Arg Trp 644
Authors
Cooke TF; Fischer CR; Wu P; Jiang TX; Xie KT; Kuo J; Doctorov E; Zehnder A; et al. ... show more
Abstract
Parrot feathers contain red, orange, and yellow polyene pigments called psittacofulvins. Budgerigars are parrots that have been extensively bred for plumage traits during the last century, but the underlying genes are unknown. Here we use genome-wide association mapping and gene-expression analysis to map the Mendelian blue locus, which abolishes yellow pigmentation in the budgerigar. We find that the blue trait maps to a single amino acid substitution (R644W) in an uncharacterized polyketide synthase (MuPKS). When we expressed MuPKS heterologously in yeast, yellow pigments accumulated. Mass spectrometry confirmed that these yellow pigments match those found in feathers. The R644W substitution abolished MuPKS activity. Furthermore, gene-expression data from feathers of different bird species suggest that parrots acquired their colors through regulatory changes that drive high expression of MuPKS in feather epithelia. Our data also help formulate biochemical models that may explain natural color variation in parrots. VIDEO ABSTRACT.

Copyright © 2017 Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
https://omia.org/OMIA001701/13146/
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