GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002123
Main curator
Santos
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Stripes
Trait State in Taxon B
Absence of stripes
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
zebrafish
Synonyms
Brachydanio rerio; Brachydanio rerio frankei; Cyprinus rerio; Danio frankei; Danio rerio frankei; zebrafish; leopard danio; zebra danio; zebra fish; Cyprinus rerio Hamilton, 1822; Danio rerio (Hamilton, 1822); Brachidanio rerio
Rank
species
Lineage
Show more ... ; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
pearl danio
Synonyms
Brachydanio albolineatus; pearl danio; Danio albolineatus (Blyth, 1860)
Rank
species
Lineage
Show more ... ; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
csf1a
Synonyms
-
String
-
Sequence Similarities
-
GO - Biological Process
-
UniProtKB
Danio rerio
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
-
Experimental Evidence
Authors
Patterson LB; Bain EJ; Parichy DM
Abstract
Fishes have diverse pigment patterns, yet mechanisms of pattern evolution remain poorly understood. In zebrafish, Danio rerio, pigment-cell autonomous interactions generate dark stripes of melanophores that alternate with light interstripes of xanthophores and iridophores. Here, we identify mechanisms underlying the evolution of a uniform pattern in D. albolineatus in which all three pigment cell classes are intermingled. We show that in this species xanthophores differentiate precociously over a wider area, and that cis regulatory evolution has increased expression of xanthogenic Colony Stimulating Factor-1 (Csf1). Expressing Csf1 similarly in D. rerio has cascading effects, driving the intermingling of all three pigment cell classes and resulting in the loss of stripes, as in D. albolineatus. Our results identify novel mechanisms of pattern development and illustrate how pattern diversity can be generated when a core network of pigment-cell autonomous interactions is coupled with changes in pigment cell differentiation.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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