GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00002127
Main curator
Santos
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Mallard pigmentation pattern
Trait State in Taxon B
Pekin pigmentation (white)
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
mallard
Synonyms
Anas boschas; Anas domesticus; Anas platyrhynchos f. domestica; mallard; duck; mallard duck; mallard ducks; Anas platyrhynchos Linnaeus 1758; Anas platyrhynchus
Rank
species
Lineage
Show more ... podomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; Anatinae; Anas
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Wild mallard ducks
Taxon B
Common Name
mallard
Synonyms
Anas boschas; Anas domesticus; Anas platyrhynchos f. domestica; mallard; duck; mallard duck; mallard ducks; Anas platyrhynchos Linnaeus 1758; Anas platyrhynchus
Rank
species
Lineage
Show more ... podomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae; Anatinae; Anas
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Domesticated breed
GENOTYPIC CHANGE
Generic Gene Name
Mitf
Synonyms
Wh; bw; mi; vit; BCC2; Bhlhe32; Gsfbcc2; Vitiligo; Bw; Mi; Vit
Sequence Similarities
Belongs to the MiT/TFE family.
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
6.6kb insertion between exon 1M and exon 2, leads to lower expression of isoform MITF M in pekin white ducks
Experimental Evidence
Authors
Zhou Z; Li M; Cheng H; Fan W; Yuan Z; Gao Q; Xu Y; Guo Z; et al. ... show more
Abstract
Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the selection signatures using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, the phenotypes are fine-mapped based on resequencing of 1026 ducks from an F segregating population generated by wild × domestic crosses. Interestingly, the two key economic traits of Pekin duck are associated with two selective sweeps with fixed mutations. A novel intronic insertion most possibly leads to a splicing change in MITF accounted for white duck down feathers. And a putative long-distance regulatory mutation causes continuous expression of the IGF2BP1 gene after birth which increases body size by 15% and feed efficiency by 6%. This study provides new insights into genotype-phenotype associations in animal research and constitutes a promising resource on economically important genes in fowl.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
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