GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002137
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
X. malinche = no "spotted caudal" trait but hybrids develop melanoma
Trait State in Taxon B
X. birchmanni with “spotted caudal” trait = a dark blotch on the caudal fin generated by clusters of macromelanocyte cells
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
sheepshead swordtail
Synonyms
sheepshead swordtail; Xiphophorus birchmanni Lechner & Radda, 1987
Rank
species
Lineage
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oteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Xiphophorus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
highland swordtail
Synonyms
highland swordtail; Xiphophorus malinche Rauchenberger, Kallman & Morizot, 1990
Rank
species
Lineage
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oteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Xiphophorus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
xmrk
Synonyms
tu
String
-
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
GO - Molecular Function
GO:0005524 : ATP binding
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GO - Biological Process
GO - Cellular Component
UniProtKB
Xiphophorus maculatus
Xiphophorus maculatus
Presumptive Null
Molecular Type
Aberration Type
Deletion Size
unknown
Molecular Details of the Mutation
Loss of Xmrk in several Xiphophorus species
Experimental Evidence
Main Reference
Authors
Powell DL; García-Olazábal M; Keegan M; Reilly P; Du K; Díaz-Loyo AP; Banerjee S; Blakkan D; et al.
... show more
Abstract
The establishment of reproductive barriers between populations can fuel the evolution of new species. A genetic framework for this process posits that "incompatible" interactions between genes can evolve that result in reduced survival or reproduction in hybrids. However, progress has been slow in identifying individual genes that underlie hybrid incompatibilities. We used a combination of approaches to map the genes that drive the development of an incompatibility that causes melanoma in swordtail fish hybrids. One of the genes involved in this incompatibility also causes melanoma in hybrids between distantly related species. Moreover, this melanoma reduces survival in the wild, likely because of progressive degradation of the fin. This work identifies genes underlying a vertebrate hybrid incompatibility and provides a glimpse into the action of these genes in natural hybrid populations.
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Epistasis interaction with a second loci thought to be in cd97 gene (unknown if regulatory or coding change)
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