GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002173
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Syrian Hamster - WT hair
Trait State in Taxon B
Male-dominant long-haired coat (MALC) ; autosomal recessive
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
golden hamster
Synonyms
Golden hamsters; Syrian hamsters; golden hamster; Syrian golden hamster; Syrian golden hamsters; Syrian hamster; Mesocricetus auratus Waterhouse, 1839
Rank
species
Lineage
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stomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
golden hamster
Synonyms
Golden hamsters; Syrian hamsters; golden hamster; Syrian golden hamster; Syrian golden hamsters; Syrian hamster; Mesocricetus auratus Waterhouse, 1839
Rank
species
Lineage
Show more ...
stomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Fgf5
Synonyms
go; Fgf-5; HBGF-5; angora
String
Sequence Similarities
Belongs to the heparin-binding growth factors family.
GO - Molecular Function
GO:0008083 : growth factor activity
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GO - Biological Process
GO:0008283 : cell proliferation
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GO - Cellular Component
Presumptive Null
Molecular Type
Aberration Type
Deletion Size
1-9 bp
Molecular Details of the Mutation
c.546delG p.Arg184GlyfsX6
Experimental Evidence
Authors
Yoshizawa Y; Wada K; Shimoi G; Shiomi G; Kameyama Y; Wakabayashi Y; Fukuta K; Hashizume R
Abstract
Hair length in mammals is generally regulated by the hair cycle, and its disruption leads to abnormal hair morphogenesis in several species. FGF5, one of the hair cycle regulators, has a role in inducing catagen, and that mutation causes abnormal hair length in both sexes in humans, mice, dogs, and cats. Male-dominant long-haired coat (MALC) is an inbred strain of Syrian hamster exhibiting spontaneous long hair in males. After castration, MALC exhibited significantly shorter hair than the control individuals, but testosterone administration to castrated MALC showed reversion to the original phenotype. Moreover, flutamide administration led to MALC phenotype repression. Histological analysis revealed that hair follicle regression was shown in the wild-type 4 weeks after depilation, but that of MALC remained in the anagen phase. We detected a c.546delG of Fgf5 in MALC (Fgf5malc) that might lead to truncation resulting from a frame shift in FGF5 (p.Arg184GlyfsX6). Additionally, homozygous Fgf5malc was only detected in long-haired (Slc:Syrian×MALC)F2 and (J-2-Nn×MALC)F2 progenies, and all homozygous wild and heterozygous Fgf5malc individuals showed normal hair length. Thus, Fgf5malc leads to male-dominant long hair via a prolonged anagen phase which is affected by testosterone in hamsters. To our knowledge, this report is the first to present the sexual dimorphism of hair length caused by the Fgf5 mutation.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@SexualDimorphism https://omia.org/OMIA000439/10036/
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