GEPHE SUMMARY Print
Gephebase Gene
FGF5
Entry Status
Published
GepheID
GP00002178
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Morphology
Trait
Hair length
Trait State in Taxon A
domestic guinea pig with WT hair
Trait State in Taxon B
domestic guinea pig with long (angora) hair ; recessive
Ancestral State
Taxon A
Taxonomic Status
Domesticated
Taxon A
Latin Name
Cavia porcellus
Common Name
domestic guinea pig
Synonyms
Cavia aperea porcellus; Cavia cobaya; domestic guinea pig; guinea pig; Cavia cobya
Rank
species
Lineage
Show more ... omata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Parent
Cavia (guinea pigs) - (Rank: genus)
NCBI Taxonomy ID
10141
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Cavia porcellus
Common Name
domestic guinea pig
Synonyms
Cavia aperea porcellus; Cavia cobaya; domestic guinea pig; guinea pig; Cavia cobya
Rank
species
Lineage
Show more ... omata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Parent
Cavia (guinea pigs) - (Rank: genus)
NCBI Taxonomy ID
10141
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Fgf5
Synonyms
go; Fgf-5; HBGF-5; angora
String
10090.ENSMUSP00000031280
Sequence Similarities
Belongs to the heparin-binding growth factors family.
GO - Molecular Function
GO:0008083 : growth factor activity ... show more
GO - Biological Process
GO:0008283 : cell proliferation ... show more
GO - Cellular Component
GO:0005576 : extracellular region
UniProtKB
Mus musculus
P15656
GenebankID or UniProtKB
ABB87177
Presumptive Null
Yes
Molecular Type
Coding
Aberration Type
SNP
SNP Coding Change
Nonsense
Molecular Details of the Mutation
c.403C>T p.Arg135*
Experimental Evidence
Candidate Gene
Taxon A Taxon B Position
Codon - - -
Amino-acid Arg STP 135
Main Reference
A nonsense mutation in the FGF5 gene is associated with the long-haired phenotype in domestic guinea pigs (Cavia porcellus). (2018)
Authors
Yu F; Liu Z; Jiao S; Zhang X; Bai C; Zhang J; Yan S
Abstract
-
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
https://omia.org/OMIA000439/10141/
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