GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000221
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila melanogaster - African and Caribbean - desat2[7-11HD-low] allele
Trait State in Taxon B
Drosophila melanogaster - other areas - Desat2[5-9HD-low] allele
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Desat2
Synonyms
7-11HD; CG5925; desat; desat-2; desat2; desat2/Fad; Dmel\CG5925; ds2; Fad; desat 2; Dmel_CG5925
Sequence Similarities
Belongs to the fatty acid desaturase type 1 family.
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Deletion Size
10-99 bp
Molecular Details of the Mutation
16bp deletion about 150bp upstream of transcription start site
Experimental Evidence
Authors
Takahashi A; Tsaur SC; Coyne JA; Wu CI
Abstract
The cuticular hydrocarbon (CH) pheromones in Drosophila melanogaster exhibit strong geographic variation. African and Caribbean populations have a high ratio of 5,9 heptacosadiene/7,11 heptacosadiene (the "High" CH type), whereas populations from all other areas have a low ratio ("Low" CH type). Based on previous genetic mapping, DNA markers were developed that localized the genetic basis of this CH polymorphism to within a 13-kb region. We then carried out a hierarchical search for diagnostic nucleotide sites starting with four lines, and increasing to 24 and 43 lines from a worldwide collection. Within the 13-kb region, only one variable site shows a complete concordance with the CH phenotype. This is a 16-bp deletion in the 5' region of a desaturase gene (desat2) that was recently suggested to be responsible for the CH polymorphism on the basis of its expression [Dallerac, R., Labeur, C., Jallon, J.-M., Knipple, D. C., Roelofs, W. L. & Wicker-Thomas, C. (2000) Proc. Natl. Acad. Sci. 97, 9449--9454]. The cosmopolitan Low type is derived from the ancestral High type, and DNA sequence variations suggest that the former spread worldwide with the aid of positive selection. Whether this CH variation could be a component of the sexual isolation between Zimbabwe and other cosmopolitan populations remains an interesting and unresolved question.
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
@SexualTrait - The cosmopolitan desat2[5-9HD-low] allele is derived from the ancestral desat2[7-11HD-low] allele and has spread worldwide. - http://flybase.org/reports/FBal0095912.html - http://flybase.org/reports/FBal0147210.html - http://flybase.org/reports/FBal0230316
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