GEPHE SUMMARY Print
Gephebase Gene
tyrosinase-related protein 1 (TYRP1)
Entry Status
Published
GepheID
GP00002235
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Morphology
Trait
Coloration (coat)
Trait State in Taxon A
Canis familiaris - various breeds
Trait State in Taxon B
Canis familiaris - Lancashire heeler
Ancestral State
Taxon A
Taxonomic Status
Domesticated
Taxon A
Latin Name
Canis lupus
Common Name
gray wolf
Synonyms
gray wolf; grey wolf; Canis lupus Linnaeus, 1758
Rank
species
Lineage
Show more ... rata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Parent
Canis () - (Rank: genus)
NCBI Taxonomy ID
9612
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Canis lupus familiaris
Common Name
dog
Synonyms
Canis canis; Canis domesticus; Canis familiaris; dog; dogs; Canis familiaris Linnaeus, 1758; Canis lupus familiaris Linnaeus, 1758
Rank
subspecies
Lineage
Show more ... tomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis; Canis lupus
Parent
Canis lupus (gray wolf) - (Rank: species)
NCBI Taxonomy ID
9615
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Tyrp1
Synonyms
b; isa; Oca3; TRP1; Tyrp; TRP-1; brown; Tyrp-1
String
10090.ENSMUSP00000006151
Sequence Similarities
Belongs to the tyrosinase family.
GO - Molecular Function
GO:0042803 : protein homodimerization activity ... show more
GO - Biological Process
GO:0032438 : melanosome organization ... show more
GO - Cellular Component
GO:0016021 : integral component of membrane ... show more
UniProtKB
Mus musculus
P07147
GenebankID or UniProtKB
AAK96019
Presumptive Null
No
Molecular Type
Coding
Aberration Type
SNP
SNP Coding Change
Nonsense
Molecular Details of the Mutation
c.1025T>G p.Phe342Cys
Experimental Evidence
Candidate Gene
Taxon A Taxon B Position
Codon - - -
Amino-acid Phe Cys 342
Main Reference
A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers. (2019)
Authors
Wright HE; Schofield E; Mellersh CS; Burmeister LM
Abstract
-
Additional References
RELATED GEPHE
Related Genes
13 (Agouti (ASIP), GPR22, MFSD12, PMEL17, SLC45A2=MATP, FGF3; FGF4; FGF19; ORAOV1, Kit, MC1R, Melanophilin (MLPH), Microphtalmia-associated transcription factor, PSMB7, beta-defensin 103 (CBD103), RALY (hnRNP associated with lethal yellow))
Related Haplotypes
4
EXTERNAL LINKS
COMMENTS
@AllelicSeries https://omia.org/OMIA001249/9615/
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