GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002347
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
presence of dorsal fin
wild goldfish and many strains of domesticated goldfish
wild goldfish and many strains of domesticated goldfish
Trait State in Taxon B
absence of dorsal fin
8 strains of domesticated goldfish
8 strains of domesticated goldfish
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
goldfish
Synonyms
Carassius carassius auratus; Cyprinus auratus; goldfish; Carassius auratus (Linnaeus, 1758); Cyprinus auratus Linnaeus, 1758; Carassius auratis
Rank
species
Lineage
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Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Cyprininae; Carassius
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
goldfish
Synonyms
Carassius carassius auratus; Cyprinus auratus; goldfish; Carassius auratus (Linnaeus, 1758); Cyprinus auratus Linnaeus, 1758; Carassius auratis
Rank
species
Lineage
Show more ...
Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Cyprininae; Carassius
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Lrp6
Synonyms
Cd; Gw; ska26; skax26; ska<m26Jus>; C030016K15Rik
String
Sequence Similarities
Belongs to the LDLR family.
GO - Molecular Function
GO:0042802 : identical protein binding
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GO - Biological Process
GO:0003401 : axis elongation
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GO - Cellular Component
GO:0016021 : integral component of membrane
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UniProtKB
Mus musculus
Mus musculus
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Lrp6 gene expression is reduced in goldfish with the dorsal fin loss phenotype. Only four amino acid substitutions in the coding region and all of them are conserved or semi-conserved in zebrafish or medaka lrp6 orthologs. There is a 313-bp deletion in intron 21 of lrp6S in goldfish with the dorsal fin loss phenotype. This intronic deletion may affect induction and proper production of lrp6S mRNA at embryonic stages.
Experimental Evidence
Authors
Kon T; Omori Y; Fukuta K; Wada H; Watanabe M; Chen Z; Iwasaki M; Mishina T; et al.
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Abstract
Although domesticated goldfish strains exhibit highly diversified phenotypes in morphology, the genetic basis underlying these phenotypes is poorly understood. Here, based on analysis of transposable elements in the allotetraploid goldfish genome, we found that its two subgenomes have evolved asymmetrically since a whole-genome duplication event in the ancestor of goldfish and common carp. We conducted whole-genome sequencing of 27 domesticated goldfish strains and wild goldfish. We identified more than 60 million genetic variations and established a population genetic structure of major goldfish strains. Genome-wide association studies and analysis of strain-specific variants revealed genetic loci associated with several goldfish phenotypes, including dorsal fin loss, long-tail, telescope-eye, albinism, and heart-shaped tail. Our results suggest that accumulated mutations in the asymmetrically evolved subgenomes led to generation of diverse phenotypes in the goldfish domestication history. This study is a key resource for understanding the genetic basis of phenotypic diversity among goldfish strains.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Loss of Lrp6 activity in zebrafish gives rise to a similar fin phenotype.
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