GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002348
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
median and paired fins of standard size
wild goldfish and many strains of domesticated goldfish
wild goldfish and many strains of domesticated goldfish
Trait State in Taxon B
elongation of all median and paired fins
14 strains of domesticated goldfish
14 strains of domesticated goldfish
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
goldfish
Synonyms
Carassius carassius auratus; Cyprinus auratus; goldfish; Carassius auratus (Linnaeus, 1758); Cyprinus auratus Linnaeus, 1758; Carassius auratis
Rank
species
Lineage
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Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Cyprininae; Carassius
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
goldfish
Synonyms
Carassius carassius auratus; Cyprinus auratus; goldfish; Carassius auratus (Linnaeus, 1758); Cyprinus auratus Linnaeus, 1758; Carassius auratis
Rank
species
Lineage
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Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Cyprininae; Carassius
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
KCNK5
Synonyms
TASK2; K2p5.1; KCNK5b; TASK-2
String
Sequence Similarities
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
GO - Molecular Function
GO:0005249 : voltage-gated potassium channel activity
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GO - Biological Process
GO:0006813 : potassium ion transport
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GO - Cellular Component
UniProtKB
Homo sapiens
Homo sapiens
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Substitution of a hydrophobic amino acid (valine) with a hydrophilic amino acid (glutamic acid) appears to cause a critical alteration of channel gating. In total there are five amino acid substitutions or deletions in kcnk5bS in goldfish with the long-tail phenotype.
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | GTA | GAA | - |
| Amino-acid | Val | Glu | 165 |
Authors
Kon T; Omori Y; Fukuta K; Wada H; Watanabe M; Chen Z; Iwasaki M; Mishina T; et al.
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Abstract
Although domesticated goldfish strains exhibit highly diversified phenotypes in morphology, the genetic basis underlying these phenotypes is poorly understood. Here, based on analysis of transposable elements in the allotetraploid goldfish genome, we found that its two subgenomes have evolved asymmetrically since a whole-genome duplication event in the ancestor of goldfish and common carp. We conducted whole-genome sequencing of 27 domesticated goldfish strains and wild goldfish. We identified more than 60 million genetic variations and established a population genetic structure of major goldfish strains. Genome-wide association studies and analysis of strain-specific variants revealed genetic loci associated with several goldfish phenotypes, including dorsal fin loss, long-tail, telescope-eye, albinism, and heart-shaped tail. Our results suggest that accumulated mutations in the asymmetrically evolved subgenomes led to generation of diverse phenotypes in the goldfish domestication history. This study is a key resource for understanding the genetic basis of phenotypic diversity among goldfish strains.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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