GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002352
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
wild-type coloration
Trait State in Taxon B
absence of all black and brown pigmentation in the skin; iris and retina
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
goldfish
Synonyms
Carassius carassius auratus; Cyprinus auratus; goldfish; Carassius auratus (Linnaeus, 1758); Cyprinus auratus Linnaeus, 1758; Carassius auratis
Rank
species
Lineage
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Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Cyprininae; Carassius
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
goldfish
Synonyms
Carassius carassius auratus; Cyprinus auratus; goldfish; Carassius auratus (Linnaeus, 1758); Cyprinus auratus Linnaeus, 1758; Carassius auratis
Rank
species
Lineage
Show more ...
Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Cyprininae; Carassius
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Oca2
Synonyms
p; D7Nic1; p<cas>; D7H15S12; D7Icr28RN; P
String
Sequence Similarities
Belongs to the CitM (TC 2.A.11) transporter family.
GO - Molecular Function
-
GO - Biological Process
GO:0055085 : transmembrane transport
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GO - Cellular Component
GO:0016021 : integral component of membrane
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Presumptive Null
Molecular Type
Aberration Type
Deletion Size
1-9 bp
Molecular Details of the Mutation
1-bp deletion creating a frameshift and a truncated protein (519 amino acids instead of 805). In oca2S ohnolog on chromosome LG31.
Experimental Evidence
Authors
Kon T; Omori Y; Fukuta K; Wada H; Watanabe M; Chen Z; Iwasaki M; Mishina T; et al.
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Abstract
Although domesticated goldfish strains exhibit highly diversified phenotypes in morphology, the genetic basis underlying these phenotypes is poorly understood. Here, based on analysis of transposable elements in the allotetraploid goldfish genome, we found that its two subgenomes have evolved asymmetrically since a whole-genome duplication event in the ancestor of goldfish and common carp. We conducted whole-genome sequencing of 27 domesticated goldfish strains and wild goldfish. We identified more than 60 million genetic variations and established a population genetic structure of major goldfish strains. Genome-wide association studies and analysis of strain-specific variants revealed genetic loci associated with several goldfish phenotypes, including dorsal fin loss, long-tail, telescope-eye, albinism, and heart-shaped tail. Our results suggest that accumulated mutations in the asymmetrically evolved subgenomes led to generation of diverse phenotypes in the goldfish domestication history. This study is a key resource for understanding the genetic basis of phenotypic diversity among goldfish strains.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
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