GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002364
Main curator
Santos
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Stripes
Trait State in Taxon B
Bars
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
zebrafish
Synonyms
Brachydanio rerio; Brachydanio rerio frankei; Cyprinus rerio; Danio frankei; Danio rerio frankei; zebrafish; leopard danio; zebra danio; zebra fish; Cyprinus rerio Hamilton, 1822; Danio rerio (Hamilton, 1822); Brachidanio rerio
Rank
species
Lineage
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; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
Danio aesculapii Kullander & Fang, 2009
Rank
species
Lineage
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mi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Danionidae; Danioninae; Danio
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Kcnj13
Synonyms
Kir7.1
String
Sequence Similarities
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ13 subfamily.
GO - Molecular Function
GO - Biological Process
GO:1990573 : potassium ion import across plasma membrane
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GO - Cellular Component
GO:0016021 : integral component of membrane
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UniProtKB
Mus musculus
Mus musculus
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
-
Experimental Evidence
Main Reference
Authors
Podobnik M; Frohnhöfer HG; Dooley CM; Eskova A; Nüsslein-Volhard C; Irion U
Abstract
The genetic basis of morphological variation provides a major topic in evolutionary developmental biology. Fish of the genus Danio display colour patterns ranging from horizontal stripes, to vertical bars or spots. Stripe formation in zebrafish, Danio rerio, is a self-organizing process based on cell-contact mediated interactions between three types of chromatophores with a leading role of iridophores. Here we investigate genes known to regulate chromatophore interactions in zebrafish that might have evolved to produce a pattern of vertical bars in its sibling species, Danio aesculapii. Mutant D. aesculapii indicate a lower complexity in chromatophore interactions and a minor role of iridophores in patterning. Reciprocal hemizygosity tests identify the potassium channel gene obelix/Kcnj13 as evolved between the two species. Complementation tests suggest evolutionary change through divergence in Kcnj13 function in two additional Danio species. Thus, our results point towards repeated and independent evolution of this gene during colour pattern diversification.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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