GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002403
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
WT Bombyx mori strains (p50 and N4) and non-domesticated Bombyx mandarina
Trait State in Taxon B
Bombyx mori - Caltrop-type multilunar (LC) phenotype with periodic patterns
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
domestic silkworm
Synonyms
domestic silkworm; silk moth; silkworm; Bombyx mori Linnaeus, 1758
Rank
species
Lineage
Show more ... xapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea; Bombycidae; Bombycinae; Bombyx
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
WT Bombyx mori strains (p50 and N4) and non-domesticated Bombyx mandarina
Taxon B
Latin Name
Common Name
domestic silkworm
Synonyms
domestic silkworm; silk moth; silkworm; Bombyx mori Linnaeus, 1758
Rank
species
Lineage
Show more ... xapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea; Bombycidae; Bombycinae; Bombyx
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Bombyx mori - Caltrop-type multilunar (LC) phenotype with periodic patterns
GENOTYPIC CHANGE
Generic Gene Name
wg
Synonyms
I; beta-catenin; Br; CG4889; Dint-1; Dm Wg; Dm-1; Dmel\CG4889; DWint-1; dWnt; DWnt-1; fg; Gla; int-1; l(2)02657; l(2)rO727; l(2)SH1281; l(2)SH2 1281; l(2)wg; Sp; spd; Wg; WG; wgl; wnt; Wnt; WNT; Wnt-1; Wnt/Wg; wnt1; Wnt1
Sequence Similarities
Belongs to the Wnt family.
GO - Biological Process
GO:0061382 : Malpighian tubule tip cell differentiation ... show more
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Deletion Size
100-1000 kb
Molecular Details of the Mutation
A specific large deletion (271 kb) is present in the 3′-flanking region of Wnt1. Wnt1 expression is significantly higher in the epidermis of heterozygous LC (LC/+) mutants than in normal strains (+/+).
Experimental Evidence
Authors
Tong X; Han MJ; Lu K; Tai S; Liang S; Liu Y; Hu H; Shen J; et al. ... show more
Abstract
The silkworm Bombyx mori is an important economic insect for producing silk, the "queen of fabrics". The currently available genomes limit the understanding of its genetic diversity and the discovery of valuable alleles for breeding. Here, we deeply re-sequence 1,078 silkworms and assemble long-read genomes for 545 representatives. We construct a high-resolution pan-genome dataset representing almost the entire genomic content in the silkworm. We find that the silkworm population harbors a high density of genomic variants and identify 7308 new genes, 4260 (22%) core genes, and 3,432,266 non-redundant structure variations (SVs). We reveal hundreds of genes and SVs that may contribute to the artificial selection (domestication and breeding) of silkworm. Further, we focus on four genes responsible, respectively, for two economic (silk yield and silk fineness) and two ecologically adaptive traits (egg diapause and aposematic coloration). Taken together, our population-scale genomic resources will promote functional genomics studies and breeding improvement for silkworm.

© 2022. The Author(s).
Additional References
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