GEPHE SUMMARY
Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002447
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Aedes albopictus
Trait State in Taxon B
Aedes albopictus - resistant from Singapore
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
Asian tiger mosquito
Synonyms
Stegomyia albopicta; Asian tiger mosquito; forest day mosquito; Aedes albopictus (Skuse, 1894)
Rank
species
Lineage
Show more ...
Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Aedini; Aedes; Stegomyia
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Asian tiger mosquito
Synonyms
Stegomyia albopicta; Asian tiger mosquito; forest day mosquito; Aedes albopictus (Skuse, 1894)
Rank
species
Lineage
Show more ...
Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Aedini; Aedes; Stegomyia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
para
Synonyms
bas; bss; CG9907; Dmel\CG9907; DmNav; DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da; l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; sbl; sbl-1; Shu; Shudderer
String
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
GO - Molecular Function
GO:0005509 : calcium ion binding
... show more
GO - Biological Process
GO - Cellular Component
GO:0005887 : integral component of plasma membrane
... show more
UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
F1534C
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | Phe | Cys | 1534 |
Main Reference
Authors
Kasai S; Ng LC; Lam-Phua SG; Tang CS; Itokawa K; Komagata O; Kobayashi M; Tomita T
Abstract
The Asian tiger mosquito, Aedes albopictus (Skuse), is the major vector of Chikungunya fever and the secondary vector of dengue fever. We collected Ae. albopictus from Singapore and performed genotyping assay to detect mutations of the voltage-gated sodium channel, which is the target site of pyrethroid insecticides. We detected an amino acid substitution, F1534C, which is suspected to confer knockdown resistance (kdr) to pyrethroid insecticides. Of the collected mosquitoes, 53.8% were homozygous for this mutation, and the allele frequency of this mutation was estimated to be 73.1%. No kdr mutation was detected in the 5 other loci of domains II and IV. This is the first evidence for the presence of the kdr gene in Ae. albopictus, and our findings highlight the need for studying the global distribution of this allele in this important vector insect.
RELATED GEPHE
Related Genes
Related Haplotypes
EXTERNAL LINKS
COMMENTS
YOUR FEEDBACK is welcome!