GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002449
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Pectinophora gossypiella - Bt-Cry1Ac susceptible
Trait State in Taxon B
Pectinophora gossypiella - Bt-Cry1Ac resistant lab selected strain
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
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Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ...
Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
-
Synonyms
-
String
-
Sequence Similarities
-
GO - Molecular Function
GO - Biological Process
GO - Cellular Component
GO:0016021 : integral component of membrane
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UniProtKB
Helicoverpa zea
Helicoverpa zea
Presumptive Null
Molecular Type
Aberration Type
Insertion Size
-
Molecular Details of the Mutation
insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon designated CR1-1_Pg. Unlike most other CR1 elements CR1-1_Pg is intact and transcribed by a flanking promoter. It contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function.
Experimental Evidence
Main Reference
Authors
Morin S; Biggs RW; Sisterson MS; Shriver L; Ellers-Kirk C; Higginson D; Holley D; Gahan LJ; et al.
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Abstract
Evolution of resistance by pests is the main threat to long-term insect control by transgenic crops that produce Bacillus thuringiensis (Bt) toxins. Because inheritance of resistance to the Bt toxins in transgenic crops is typically recessive, DNA-based screening for resistance alleles in heterozygotes is potentially much more efficient than detection of resistant homozygotes with bioassays. Such screening, however, requires knowledge of the resistance alleles in field populations of pests that are associated with survival on Bt crops. Here we report that field populations of pink bollworm (Pectinophora gossypiella), a major cotton pest, harbored three mutant alleles of a cadherin-encoding gene linked with resistance to Bt toxin Cry1Ac and survival on transgenic Bt cotton. Each of the three resistance alleles has a deletion expected to eliminate at least eight amino acids upstream of the putative toxin-binding region of the cadherin protein. Larvae with two resistance alleles in any combination were resistant, whereas those with one or none were susceptible to Cry1Ac. Together with previous evidence, the results reported here identify the cadherin gene as a leading target for DNA-based screening of resistance to Bt crops in lepidopteran pests.
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