GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002453
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Chilo suppressalis - sensitive
Trait State in Taxon B
Chilo suppressalis - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
striped riceborer
Synonyms
Crambus suppressalis; striped riceborer; Asiatic rice borer; striped rice borer; Chilo suppressalis (Walker, 1863); Chilo supperssalis; Chilo supressalis
Rank
species
Lineage
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Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Pyraloidea; Crambidae; Crambinae; Chilo
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
striped riceborer
Synonyms
Crambus suppressalis; striped riceborer; Asiatic rice borer; striped rice borer; Chilo suppressalis (Walker, 1863); Chilo supperssalis; Chilo supressalis
Rank
species
Lineage
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Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Pyraloidea; Crambidae; Crambinae; Chilo
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Ace
Synonyms
AcChE; ace; ACE; ace-2; ache; AchE; AChE; CG17907; CHE; dAChE; dmAChE; DmAChE; Dmel\CG17907; Dm_ace; FBgn0000024; l(3)26; l(3)87Ed
String
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Molecular Function
GO:0042803 : protein homodimerization activity
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GO - Biological Process
GO:0006581 : acetylcholine catabolic process
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GO - Cellular Component
GO:0005886 : plasma membrane
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UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | Ala | Ser | 201 |
Authors
Jiang X; Qu M; Denholm I; Fang J; Jiang W; Han Z
Abstract
Two full-length genes encoding different acetylcholinesterases (AChEs), designated as Ch-ace1 and Ch-ace2, were cloned from strains of the rice stem borer (Chilo suppressalis) susceptible and resistant to the organophosphate insecticide triazophos. Sequence analysis found an amino acid mutation A314S in Ch-ace1 (corresponding to A201 in Torpedo californica AChE) that was consistently associated with the occurrence of resistance. This mutation removed an MspA1 I restriction site from the wild type allele. An assay based on restriction fragment length polymorphism (RFLP) analysis was developed to diagnose A314S genotypes in field populations. Results showed a strong correlation between frequencies of the mutation and phenotypic levels of resistance to triazophos. The assay offers a prospect for rapid monitoring of resistance and assisting with the appropriate choice of insecticide for combating damage caused by C. suppressalis.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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