GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002470
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Phlebotomus argentipes susceptible
Trait State in Taxon B
Phlebotomus argentipes resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Phlebotomus (Euphlebotomus) argentipes; Phlebotomus argentipes Annandale & Brunetti, 1908
Rank
species
Lineage
Show more ... Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Psychodomorpha; Psychodoidea; Psychodidae; Phlebotominae; Phlebotomus; Euphlebotomus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
Phlebotomus (Euphlebotomus) argentipes; Phlebotomus argentipes Annandale & Brunetti, 1908
Rank
species
Lineage
Show more ... Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Psychodomorpha; Psychodoidea; Psychodidae; Phlebotominae; Phlebotomus; Euphlebotomus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
-
Molecular Details of the Mutation
L1014F
Experimental Evidence
Taxon A Taxon B Position
Codon TTR TTY -
Amino-acid Leu Phe 1014
Authors
Balaska S; Fotakis EA; Chaskopoulou A; Vontas J
Abstract
Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key component of leishmaniasis control efforts.

We performed a literature review on the current interventions, primarily, insecticide-based used for sand fly control, as well as the global insecticide resistance (IR) status of the main sand fly vector species. Indoor insecticidal interventions, such as residual spraying and treated bed nets are the most widely deployed, while several alternative control strategies are also used in certain settings and/or are under evaluation. IR has been sporadically detected in sand flies in India and other regions, using non-standardized diagnostic bioassays. Molecular studies are limited to monitoring of known pyrethroid resistance mutations (kdr), which are present at high frequencies in certain regions.

As the leishmaniasis burden remains a major problem at a global scale, evidence-based rational use of insecticidal interventions is required to meet public health demands. Standardized bioassays and molecular markers are a prerequisite for this task, albeit are lagging behind. Experiences from other disease vectors underscore the need for the implementation of appropriate IR management (IRM) programs, in the framework of integrated vector management (IVM). The implementation of alternative strategies seems context- and case-specific, with key eco-epidemiological parameters yet to be investigated. New biotechnology-based control approaches might also come into play in the near future to further reinforce sand fly/leishmaniasis control efforts.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
1
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