GEPHE SUMMARY Print
Gephebase Gene
CYP337B3
Entry Status
Published
GepheID
GP00002481
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Physiology
Trait
Xenobiotic resistance (insecticide; pyrethroid)
Trait State in Taxon A
Helicoverpa armigera - susceptible
Trait State in Taxon B
Helicoverpa armigera - resistant strain from China - allele CYP337B3v4
Ancestral State
Taxon A
Taxonomic Status
Intraspecific
Taxon A
Latin Name
Helicoverpa armigera
Common Name
cotton bollworm
Synonyms
Heliothis (Helicoverpa) armigera; Heliothis armigera; cotton bollworm; American bollworm; corn ear worm; scarce bordered straw; tobacco budworm; Helicoverpa armigera (Hubner, 1808)
Rank
species
Lineage
Show more ... da; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Noctuoidea; Noctuidae; Heliothinae; Helicoverpa
Parent
Helicoverpa () - (Rank: genus)
NCBI Taxonomy ID
29058
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Helicoverpa armigera
Common Name
cotton bollworm
Synonyms
Heliothis (Helicoverpa) armigera; Heliothis armigera; cotton bollworm; American bollworm; corn ear worm; scarce bordered straw; tobacco budworm; Helicoverpa armigera (Hubner, 1808)
Rank
species
Lineage
Show more ... da; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Noctuoidea; Noctuidae; Heliothinae; Helicoverpa
Parent
Helicoverpa () - (Rank: genus)
NCBI Taxonomy ID
29058
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
CYP337B3
Synonyms
-
String
-
Sequence Similarities
Belongs to the cytochrome P450 family.
GO - Molecular Function
GO:0020037 : heme binding ... show more
GO - Biological Process
-
GO - Cellular Component
GO:0005789 : endoplasmic reticulum membrane
UniProtKB
Helicoverpa armigera
A0A0H3V333
GenebankID or UniProtKB
Helicoverpa armigera
A0A0H3V333
Presumptive Null
No
Molecular Type
Coding
Aberration Type
Complex Change
Molecular Details of the Mutation
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Experimental Evidence
Candidate Gene
Main Reference
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in Chinese populations of Helicoverpa armigera . (2015 )
Authors
Han Yangchun; Yu Wanting; Zhang Weiqing; Yang Yihua; Walsh Tom; Oakeshott John G; Wu Yidong
Abstract
-
Additional References
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resistance in Helicoverpa armigera. (2018)
RELATED GEPHE
Related Genes
6 (ABCA2, Aminopeptidase N (APN), cadherin, Ha_BtR, para (kdr), tetraspanin)
Related Haplotypes
7
EXTERNAL LINKS
COMMENTS
@Parallelism - Resistance to pyrethroids as a result from the formation of a chimeric P450 gene CYP337B3 has arisen multiple times during evolution of the cotton bollworm H. armigera.
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