GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002492
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Aphis gossypii
Trait State in Taxon B
Aphis gossypii - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
cotton aphid
Synonyms
cotton aphid; melon aphid; Aphis gossypii Glover, 1877; Aphis gossyppi
Rank
species
Lineage
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thropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha; Aphidoidea; Aphididae; Aphidinae; Aphidini; Aphis; Aphis
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
cotton aphid
Synonyms
cotton aphid; melon aphid; Aphis gossypii Glover, 1877; Aphis gossyppi
Rank
species
Lineage
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thropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha; Aphidoidea; Aphididae; Aphidinae; Aphidini; Aphis; Aphis
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
nAChRbeta1
Synonyms
AChR; AchR64B; AChR64B; Acr64B; AcrD; ard; Ard; ARD; beta 64B; beta1 nAChR; CG11348; CG11348-PA; CG12606; Dbeta1; Dmel\CG11348; nAChR; nAChR-beta64B; nAcR64B; nAcRbeta-64B
String
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
GO - Molecular Function
GO:0004888 : transmembrane signaling receptor activity
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GO - Biological Process
GO:0007165 : signal transduction
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GO - Cellular Component
GO:0005887 : integral component of plasma membrane
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UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
K264E
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | - | - | - |
| Amino-acid | Lys | Glu | 264 |
Main Reference
Authors
Wang ZJ; Liang CR; Shang ZY; Yu QT; Xue CB
Abstract
The melon aphid, Aphis gossypii, is an important pest of vegetables. Insecticide resistance in A. gossypii has increased due to the frequent use of insecticides. We studied the levels and mechanisms of A. gossypii resistance to imidacloprid, acetamiprid and lambda-cyhalothrin here. The resistance levels of the three insecticides in 20 populations of A. gossypii varied. When compared to the susceptible strain (Lab-SS), there were two moderate resistance (MR) populations and nine low resistance (LR) populations to imidacloprid, respectively, two MR populations and two LR populations to acetamiprid, respectively, and, five MR populations and two LR populations to λ-cyhalothrin, respectively. Gene mutation detection in the MR level populations showed arginine to threonine substitution (R81T) in three populations and lysine to glutamine substitution (K264E) in the nicotinic acetylcholine receptor (nAChR) β1 subunit in one population, respectively. No valine to isoleucine substitution (V62I) was found in the nAChR β1 subunit in any of the tested populations. The leucine to phenylalanine substitution (L1014F) in sodium channel α subunit was found in five MR populations. The relative expression of the CYP6CY13 gene was significantly upregulated in the Daiyue and Shenxian populations. The CYP6CY14 gene was significantly upregulated in Daiyue, Dongchangfu, Shenxian, Mengyin and Anqiu populations. The CYP6CY19 gene was significantly upregulated in the Dongchangfu and Mengyin populations. The relative expressions of the esterase E4 or FE4 genes were significantly upregulated in most of the MR populations. These results provide insight into the current insecticide resistance of A. gossypii and may contribute to more effective resistance management strategies.
Copyright © 2020 Elsevier Inc. All rights reserved.
Copyright © 2020 Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Haplotypes
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