GEPHE SUMMARY
Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002496
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Thrips tabaci
Trait State in Taxon B
Thrips tabaci - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
Thrips tabaci Lindeman, 1889
Rank
species
Lineage
Show more ...
; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Thysanoptera; Terebrantia; Thripoidea; Thripidae; Thripinae; Thrips
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
Thrips tabaci Lindeman, 1889
Rank
species
Lineage
Show more ...
; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Thysanoptera; Terebrantia; Thripoidea; Thripidae; Thripinae; Thrips
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
para
Synonyms
bas; bss; CG9907; Dmel\CG9907; DmNav; DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da; l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; sbl; sbl-1; Shu; Shudderer
String
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
GO - Molecular Function
GO:0005509 : calcium ion binding
... show more
GO - Biological Process
GO - Cellular Component
GO:0005887 : integral component of plasma membrane
... show more
UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Mutation #1
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
M918T+L1014F
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | Met | Thr | 918 |
Authors
Toda S; Morishita M
Abstract
In the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae), the development of resistance to pyrethroid insecticides has become a problem worldwide. To identify this species' resistance mechanism, we analyzed partial nucleotides and deduced the amino acid sequences of the para-orthologous sodium channel gene by using 10 Japanese strains of T. tabaci that have a variety of susceptibility levels to pyrethroids. Six nucleotide substitutions were found in their cDNA sequences. Three of these create amino acid substitutions, M918T, T929I, and L1014F, which are well known to be associated with knockdown resistance in some pest insects. In the five highly resistant strains, two mutations, M918T and L1014F, were always detected with wild-type sequences, suggesting that these strains have both mutations heterozygously. A moderately resistant strain was homozygous for the T929I mutation. This is the first report to identify these three major mutations within the same species.
Additional References
Mutation #2
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
M918T+L1014F
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | Leu | Phe | 1014 |
Authors
Toda S; Morishita M
Abstract
In the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae), the development of resistance to pyrethroid insecticides has become a problem worldwide. To identify this species' resistance mechanism, we analyzed partial nucleotides and deduced the amino acid sequences of the para-orthologous sodium channel gene by using 10 Japanese strains of T. tabaci that have a variety of susceptibility levels to pyrethroids. Six nucleotide substitutions were found in their cDNA sequences. Three of these create amino acid substitutions, M918T, T929I, and L1014F, which are well known to be associated with knockdown resistance in some pest insects. In the five highly resistant strains, two mutations, M918T and L1014F, were always detected with wild-type sequences, suggesting that these strains have both mutations heterozygously. A moderately resistant strain was homozygous for the T929I mutation. This is the first report to identify these three major mutations within the same species.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
EXTERNAL LINKS
COMMENTS
YOUR FEEDBACK is welcome!