GEPHE SUMMARY
Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002525
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Haematobia irritans exigua
Trait State in Taxon B
Haematobia irritans exigua - resistant
Ancestral State
Taxon A
Taxonomic Status
GENOTYPIC CHANGE
Generic Gene Name
para
Synonyms
bas; bss; CG9907; Dmel\CG9907; DmNav; DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da; l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; sbl; sbl-1; Shu; Shudderer
String
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Para subfamily.
GO - Molecular Function
GO:0005509 : calcium ion binding
... show more
GO - Biological Process
GO - Cellular Component
GO:0005887 : integral component of plasma membrane
... show more
UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
L1014F
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Rothwell JT; Morgan JA; James PJ; Brown GW; Guerrero FD; Jorgensen WK
Abstract
Resistance to synthetic pyrethroids (SP) was first recorded in buffalo flies in Australia in 1980, associated with previous use of DDT and fenvalerate. By the 1990s, resistance was widespread. Resistance to SP in the related horn fly of the Americas is associated with kdr and super-kdr mutations in a gene encoding for a voltage-gated sodium channel. We describe 7-20-fold resistance to SP in buffalo flies from south-east Queensland, present evidence of flies that are heterozygous resistant at the kdr locus and show an increase in the frequency of the resistant allele 1 month after treatment of cattle with SP.
© 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association.
© 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
YOUR FEEDBACK is welcome!