GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00002581
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Culex pipiens - sensitive
Trait State in Taxon B
Culex pipiens - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
F290V
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Alout H; Berthomieu A; Hadjivassilis A; Weill M
Abstract
In insects, selection of insecticide-insensitive acetylcholinesterase (AChE) is a very common resistance mechanism. Mosquitoes possess both AChE1 and AChE2 enzymes and insensitivity is conferred by single amino-acid changes located near the active site of the synaptic AChE1. Only two positions have been reported so far to be involved in resistance, suggesting a very high structural constraint of the AChE1 enzyme. In particular, the G119S substitution was selected in several mosquitoes' species and is now largely spread worldwide. Yet, a different type of AChE1 insensitivity was described 10 years ago in a Culex pipiens population collected in Cyprus in 1987 and fixed thereafter as the ACE-R strain. We report here the complete amino-acid sequence of the ACE-R AChE1 and show that resistance is associated with a single Phe-to-Val substitution of residue 290, which also lines the active site. Comparison of AChE1 activities of the recombinant F290V protein and ACE-R mosquito extracts confirmed the causal role of the substitution in insensitivity. Biochemical characteristics of the mutated protein indicated that the resistance level varies with the insecticide used. A molecular diagnosis test was designed to detect this mutation and was used to show that it is still present in Cyprus Island.
RELATED GEPHE
EXTERNAL LINKS
COMMENTS
@Parallelism
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