GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002600
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Panonychus citri - sensitive
Trait State in Taxon B
Panonychus citri - resistant to bifenazate
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
citrus red mite
Synonyms
citrus red mite; citrus fruit mite; Panonychus citri (McGregor, 1916); Panonnychus citri
Rank
species
Lineage
Show more ... ria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Acari; Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae; Tetranychoidea; Tetranychidae; Panonychus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
citrus red mite
Synonyms
citrus red mite; citrus fruit mite; Panonychus citri (McGregor, 1916); Panonnychus citri
Rank
species
Lineage
Show more ... ria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Chelicerata; Arachnida; Acari; Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae; Tetranychoidea; Tetranychidae; Panonychus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Mutation #1
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
G126S and A133T. These mutations did not always occur in combination.
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Gly Ser 126
Authors
Van Leeuwen T; Van Nieuwenhuyse P; Vanholme B; Dermauw W; Nauen R; Tirry L
Abstract
Bifenazate is a recently developed acaricide that is mainly used to control spider mites on a variety of crops. Although first thought to be a neurotoxin, genetic evidence obtained from bifenazate resistant Tetranychus urticae strains suggested an alternative mode of action as a Qo pocket inhibitor of the mitochondrial complex III. In this study, we reveal how bifenazate resistance in strains of Panonychus citri is maternally inherited and can confer cross-resistance to the known Qo inhibitor acequinocyl. The mitochondrial genome of P. citri was sequenced and Qo pocket mutations were shown to be linked with the resistant trait. Parallel evolution of cytochrome b mediated bifenazate resistance corroborates the alternative mode of action and yet again illustrates that care should be taken when employing Qo inhibitors as crop protection compounds.

© 2010 The Authors. Insect Molecular Biology © 2010 The Royal Entomological Society.
Additional References
Mutation #2
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
G126S and A133T. These mutations did not always occur in combination.
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Ala Thr 133
Authors
Van Leeuwen T; Van Nieuwenhuyse P; Vanholme B; Dermauw W; Nauen R; Tirry L
Abstract
Bifenazate is a recently developed acaricide that is mainly used to control spider mites on a variety of crops. Although first thought to be a neurotoxin, genetic evidence obtained from bifenazate resistant Tetranychus urticae strains suggested an alternative mode of action as a Qo pocket inhibitor of the mitochondrial complex III. In this study, we reveal how bifenazate resistance in strains of Panonychus citri is maternally inherited and can confer cross-resistance to the known Qo inhibitor acequinocyl. The mitochondrial genome of P. citri was sequenced and Qo pocket mutations were shown to be linked with the resistant trait. Parallel evolution of cytochrome b mediated bifenazate resistance corroborates the alternative mode of action and yet again illustrates that care should be taken when employing Qo inhibitors as crop protection compounds.

© 2010 The Authors. Insect Molecular Biology © 2010 The Royal Entomological Society.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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