GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002613
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Stomoxys calcitrans
Trait State in Taxon B
Stomoxys calcitrans - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
stable fly
Synonyms
Stomoxis calcitrans; stable fly; biting house fly
Rank
species
Lineage
Show more ... poda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Calyptratae; Muscoidea; Muscidae; Muscinae; Stomoxyini; Stomoxys
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
stable fly
Synonyms
Stomoxis calcitrans; stable fly; biting house fly
Rank
species
Lineage
Show more ... poda; Insecta; Dicondylia; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Calyptratae; Muscoidea; Muscidae; Muscinae; Stomoxyini; Stomoxys
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
L1014F
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Olafson PU; Kaufman PE; Duvallet G; Solórzano JA; Taylor DB; Fryxell RT
Abstract
Anecdotal evidence of pyrethroid insecticide product failure for the control of stable fly [Stomoxys calcitrans (L.)] populations in the United States and worldwide prompted us to evaluate the frequency of knockdown resistance (kdr)-type polymorphisms within the voltage-sensitive sodium channel (Vssc) gene of field collected specimens from the United States, France, Costa Rica, and Thailand. The kdr-his allele (L1014H), associated with permethrin resistance, was detected in stable flies from the 10 states sampled in the United States, as well as from Costa Rica and France (Toulouse). Field collections of stable flies from California (Modesto) and New York (Cliffton Springs) exhibited reduced susceptibility upon exposure to a diagnostic permethrin concentration of 10× LC99, but survival did not appear to strictly associate with frequency of the kdr-his allele. This suggests that there are additional resistance mechanisms contributing to the phenotype in these states. The kdr allele (L1014F) was detected for the first time in stable flies originating in France and Thailand, and an improved, DNA-based diagnostic assay was developed and validated for use in future screens for kdr and kdr-his allele frequencies from field collections. The absence of kdr in United States and Costa Rica populations suggests that the allele is currently restricted to Europe and Asia.

Published by Oxford University Press on behalf of Entomological Society of America 2019.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
1
EXTERNAL LINKS
COMMENTS
The kdr allele (L1014F) was detected in stable flies originating in France and Thailand but not in United States and Costa Rica populations.
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