GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002638
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Nilaparvata lugens - sensitive
Trait State in Taxon B
Nilaparvata lugens - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
brown planthopper
Synonyms
brown planthopper; Nilaparvata lugens (Stal, 1854); Nalaparvata lugens
Rank
species
Lineage
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; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Auchenorrhyncha; Fulgoromorpha; Fulgoroidea; Delphacidae; Delphacinae; Nilaparvata
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
brown planthopper
Synonyms
brown planthopper; Nilaparvata lugens (Stal, 1854); Nalaparvata lugens
Rank
species
Lineage
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; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Auchenorrhyncha; Fulgoromorpha; Fulgoroidea; Delphacidae; Delphacinae; Nilaparvata
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Ces1
Synonyms
CEH; Ces1; Ces-1; Ses-1; Ces1g
String
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Molecular Function
GO:0052689 : carboxylic ester hydrolase activity
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GO - Biological Process
GO:0009617 : response to bacterium
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GO - Cellular Component
GO:0005737 : cytoplasm
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UniProtKB
Mus musculus
Mus musculus
Presumptive Null
Molecular Type
Aberration Type
Insertion Size
-
Molecular Details of the Mutation
Southern analysis of genomic DNA from the Sri Lankan OP-resistant and susceptible strains suggests that the Nl-EST1 esterase gene is amplified in the resistant strain
Experimental Evidence
Authors
Small GJ; Hemingway J
Abstract
Widespread resistance to organophosphorus insecticides (OPs) in Nilaparvata lugens is associated with elevation of carboxylesterase activity. A cDNA encoding a carboxylesterase, Nl-EST1, has been isolated from an OP-resistant Sri Lankan strain of N. lugens. The full-length cDNA codes for a 547-amino acid protein with high homology to other esterases/lipases. Nl-EST1 has an N-terminal hydrophobic signal peptide sequence of 24 amino acids which suggests that the mature protein is secreted from cells expressing it. The nucleotide sequence of the homologue of Nl-EST1 in an OP-susceptible, low esterase Sri Lankan strain of N. lugens is identical to Nl-EST1. Southern analysis of genomic DNA from the Sri Lankan OP-resistant and susceptible strains suggests that Nl-EST1 is amplified in the resistant strain. Therefore, resistance to OPs in the Sri Lankan strain is through amplification of a gene identical to that found in the susceptible strain.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
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