GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002640
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Culex pipiens - sensitive
Trait State in Taxon B
Culex pipiens - resistant from Cyprus
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
B1
Synonyms
-
String
-
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
Culex pipiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Insertion Size
-
Molecular Details of the Mutation
The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.
Experimental Evidence
Authors
Poirié M; Raymond M; Pasteur N
Abstract
Two new highly active esterases were detected by starch electrophoretic studies in Culex pipiens mosquitoes from the area of Montpellier (France) and from Cyprus. We demonstrate here that both the French and the Cyprus esterases B are overproduced due to amplification of the coding gene. The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus, respectively, than in susceptible insects, whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance. RFLP comparison of the amplified region containing the esterase B gene revealed large differences between French and Cyprus mosquitoes. It thus appears that two distinct haplotypes with an esterase B gene coding an enzyme with identical electrophoretic mobility have been amplified. We therefore named the haplotypes in mosquitoes from France and Cyprus B4 and B5, respectively. The estimated genetic distance between these two haplotypes is not smaller than those observed in all pair comparisons of other known esterase B haplotypes. These results are discussed in the context of amplification phenomena.
Additional References
RELATED GEPHE
EXTERNAL LINKS
COMMENTS
@Parrallelism
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