GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002656
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila melanogaster - resistant
Trait State in Taxon B
Drosophila melanogaster - lost the resistance
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ...
Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
lectin-24A
Synonyms
AC 005149A; AC005149a; CG3410; Dmel\CG3410; lectin-24A-RA; Dmel_CG3410
String
Sequence Similarities
-
GO - Molecular Function
GO:0030246 : carbohydrate binding
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GO - Biological Process
GO - Cellular Component
GO:0005576 : extracellular region
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UniProtKB
Drosophila melanogaster
Drosophila melanogaster
Presumptive Null
Molecular Type
Aberration Type
Deletion Size
100-999 bp
Molecular Details of the Mutation
a 165bp deletion in the protein coding sequence that results in a shift in the reading frame and a premature stop codon (p.Phe217_Glu273del*)
Experimental Evidence
Main Reference
Authors
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P; Bakare Sherifat; Pitton Simone; Hsing Chi-Yun; O’Boyle Sinead; Pascual-Gil Juan; et al.
... show more
Abstract
-
Additional References
RELATED GEPHE
EXTERNAL LINKS
COMMENTS
Lectin-24A is important in the immune response that protects fruit flies against one of their main natural enemies—parasitic wasps. This immune defiance appears to be costly. Many flies carry mutated copies of this gene that are no longer functional.
@BioRxiv @CRISPR
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