GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002658
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila melanogaster - resistant
Trait State in Taxon B
Drosophila melanogaster - lost the resistance
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsense
Molecular Details of the Mutation
Q254 >STOP - point mutation that introduces a premature stop codon
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Gln STP 254
Authors
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P; Bakare Sherifat; Pitton Simone; Hsing Chi-Yun; O’Boyle Sinead; Pascual-Gil Juan; et al. ... show more
Abstract
-
Additional References
EXTERNAL LINKS
COMMENTS
Lectin-24A is important in the immune response that protects fruit flies against one of their main natural enemies—parasitic wasps. This immune defiance appears to be costly. Many flies carry mutated copies of this gene that are no longer functional. @BioRxiv @CRISPR
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