GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00002670
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Fundulus grandis - sensitive - lives in non-polluted sites
Trait State in Taxon B
Fundulus grandis - tolerant - adapted to polluted sites
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
Gulf killifish
Synonyms
Gulf killifish; Fundulus grandis Baird & Girard, 1853
Rank
species
Lineage
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leosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Fundulidae; Fundulus
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Gulf killifish
Synonyms
Gulf killifish; Fundulus grandis Baird & Girard, 1853
Rank
species
Lineage
Show more ...
leosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Fundulidae; Fundulus
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Aip
Synonyms
Ara9; Xap2; Fkbp16; AA408703; AW476050; D19Bwg1412e
String
Sequence Similarities
-
GO - Molecular Function
GO:0051082 : unfolded protein binding
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GO - Biological Process
GO:0006805 : xenobiotic metabolic process
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GO - Cellular Component
GO:0005886 : plasma membrane
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UniProtKB
Mus musculus
Mus musculus
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
exact mutation(s) unknown - very good candidate gene according to Fst and knowledge about the physiology
Experimental Evidence
Main Reference
Authors
Oziolor EM; Reid NM; Yair S; Lee KM; Guberman VerPloeg S; Bruns PC; Shaw JR; Whitehead A; et al.
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Abstract
Radical environmental change that provokes population decline can impose constraints on the sources of genetic variation that may enable evolutionary rescue. Adaptive toxicant resistance has rapidly evolved in Gulf killifish (Fundulus grandis) that occupy polluted habitats. We show that resistance scales with pollution level and negatively correlates with inducibility of aryl hydrocarbon receptor (AHR) signaling. Loci with the strongest signatures of recent selection harbor genes regulating AHR signaling. Two of these loci introgressed recently (18 to 34 generations ago) from Atlantic killifish (F. heteroclitus). One introgressed locus contains a deletion in AHR that confers a large adaptive advantage [selection coefficient (s) = 0.8]. Given the limited migration of killifish, recent adaptive introgression was likely mediated by human-assisted transport. We suggest that interspecies connectivity may be an important source of adaptive variation during extreme environmental change.
Copyright © 2019, American Association for the Advancement of Science.
Copyright © 2019, American Association for the Advancement of Science.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Fitness Probably @Introgression from Fundulus heteroclitus
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