GEPHE SUMMARY Print
Gephebase Gene
Acetylcholinesterase (Ace-1)
Entry Status
Published
GepheID
GP00000027
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Physiology
Trait
Xenobiotic resistance (insecticide)
Trait State in Taxon A
Anopheles gambiae - sensitive
Trait State in Taxon B
Anopheles gambiae - resistant
Ancestral State
Taxon A
Taxonomic Status
Intraspecific
Taxon A
Latin Name
Anopheles gambiae
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
Show more ... tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
Parent
gambiae species complex () - (Rank: no rank)
NCBI Taxonomy ID
7165
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Anopheles gambiae
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
Show more ... tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
Parent
gambiae species complex () - (Rank: no rank)
NCBI Taxonomy ID
7165
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Ace
Synonyms
AcChE; ace; ACE; ace-2; ache; AchE; AChE; CG17907; CHE; dAChE; dmAChE; DmAChE; Dmel\CG17907; Dm_ace; FBgn0000024; l(3)26; l(3)87Ed
String
7227.FBpp0289713
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Molecular Function
GO:0042803 : protein homodimerization activity ... show more
GO - Biological Process
GO:0006581 : acetylcholine catabolic process ... show more
GO - Cellular Component
GO:0005886 : plasma membrane ... show more
UniProtKB
Drosophila melanogaster
P07140
GenebankID or UniProtKB
AKO62938
Presumptive Null
No
Molecular Type
Coding
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
G119S
Experimental Evidence
Candidate Gene
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Main Reference
Comparative genomics: Insecticide resistance in mosquito vectors. (2003)
Authors
Weill M; Lutfalla G; Mogensen K; Chandre F; Berthomieu A; Berticat C; Pasteur N; Philips A; et al. ... show more
Abstract
-
Additional References
RELATED GEPHE
Related Genes
3 (para (kdr), resistance to dieldrin, SAP-2)
Related Haplotypes
3
EXTERNAL LINKS
COMMENTS
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