GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000276
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Streptopelia risoria - No crest (dominant)
Trait State in Taxon B
Streptopelia risoria - Crest (recessive)
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
ringneck dove
Synonyms
Columba risoria; Streptopelia roseogrisea risoria; ringneck dove; Streptopelia roseogrisea risoria (Linnaeus, 1758)
Rank
species
Lineage
Show more ... i; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Streptopelia
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
ringneck dove
Synonyms
Columba risoria; Streptopelia roseogrisea risoria; ringneck dove; Streptopelia roseogrisea risoria (Linnaeus, 1758)
Rank
species
Lineage
Show more ... i; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Streptopelia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
EPHB2
Synonyms
CEK5
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
UniProtKB
Gallus gallus
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Gly636Arg (G>A)
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Gly Arg 636
Authors
Vickrey AI; Domyan ET; Horvath MP; Shapiro MD
Abstract
Head crests are important display structures in wild bird species and are also common in domesticated lineages. Many breeds of domestic rock pigeon (Columba livia) have crests of reversed occipital feathers, and this recessive trait is associated with a nonsynonymous coding mutation in the intracellular kinase domain of EphB2 (Ephrin receptor B2). The domestic ringneck dove (Streptopelia risoria) also has a recessive crested morph with reversed occipital feathers, and interspecific crosses between crested doves and pigeons produce crested offspring, suggesting a similar genetic basis for this trait in both species. We therefore investigated EphB2 as a candidate for the head crest phenotype of ringneck doves and identified a nonsynonymous coding mutation in the intracellular kinase domain that is significantly associated with the crested morph. This mutation is over 100 amino acid positions away from the crest mutation found in rock pigeons, yet both mutations are predicted to negatively affect the function of ATP-binding pocket. Furthermore, bacterial toxicity assays suggest that "crest" mutations in both species severely impact kinase activity. We conclude that head crests are associated with different mutations in the same functional domain of the same gene in two different columbid species, thereby representing striking evolutionary convergence in morphology and molecules.

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Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Parallelism ; https://omia.org/OMIA000240/328808/
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