GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000028
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Culex pipiens - sensitive
Trait State in Taxon B
Culex pipiens fasciatus - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
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lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
northern house mosquito
Synonyms
Culex agilis; Culex autogenicus; Culex azoriensis; Culex bicolor; Culex bifurcatus; Culex calcitrans; Culex calloti; Culex comitatus; Culex consobrinus; Culex dipseticus; Culex disjunctus; Culex doliorum; Culex domesticus; Culex erectus; Culex fasciatus; Culex haematophagus; Culex longefurcatus; Culex luteus; Culex marginalis; Culex melanorhinus; Culex meridionalis; Culex osakaensis; Culex pallipes; Culex phytophagus; Culex quasimodestus; Culex rufinus; Culex rufus; Culex sternopunctatus; Culex thoracicus; Culex torridus; Culex trifurcatus; Culex unistriatus; Culex varioannulatus; northern house mosquito; Culex pipiens Linnaeus, 1758
Rank
species
Lineage
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lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Ace
Synonyms
AcChE; ace; ACE; ace-2; ache; AchE; AChE; CG17907; CHE; dAChE; dmAChE; DmAChE; Dmel\CG17907; Dm_ace; FBgn0000024; l(3)26; l(3)87Ed
String
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Molecular Function
GO:0042803 : protein homodimerization activity
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GO - Biological Process
GO:0006581 : acetylcholine catabolic process
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GO - Cellular Component
GO:0005886 : plasma membrane
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | - | - | - |
| Amino-acid | - | - | - |
Authors
Weill M; Lutfalla G; Mogensen K; Chandre F; Berthomieu A; Berticat C; Pasteur N; Philips A; et al.
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Abstract
-
Additional References
RELATED GEPHE
Related Haplotypes
EXTERNAL LINKS
COMMENTS
@Parallelism - Resistance is found in each subspecies of C. pipiens. A unique haplotype was found to be associated with the resistance within each subspecies. This indicates that the same G119S mutation has occurred independently at least twice in C. pipiens; once in each subspecies.
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