GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000290
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Culex tritaeniorynchus - sensitive
Trait State in Taxon B
Culex tritaeniorynchus - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
Culex tritaeniorhynchus Giles, 1901
Rank
species
Lineage
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da; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
Culex tritaeniorhynchus Giles, 1901
Rank
species
Lineage
Show more ...
da; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
B1
Synonyms
-
String
-
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Molecular Function
GO - Biological Process
-
GO - Cellular Component
-
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Whole gene amplification
Experimental Evidence
Main Reference
Authors
Karunaratne SH; Vaughan A; Paton MG; Hemingway J
Abstract
Culex tritaeniorhynchus, the major vector of Japanese encephalitis in Sri Lanka, is resistant to organophosphorus insecticides, with a 10-fold resistance ratio at the LC50 for chlorpyrifos, and a high heterogenelty factor in the insect field population. The major mechanism of resistance in this species, as in the mosquito C. quinquefasciatus, is elevation of esterase activity. Basic biochemical, immunological and molecular analysis suggests that the C. tritaeniorhynchus CtrEstbeta1 gene is orthologous to the C. quinquefasciatus amplified Estbetas. The Estbeta2(1) antiserum cross-reacts strongly with CtrEstbeta1(1). Its corresponding cDNA, over the 545 base pairs sequenced, has approximately 84% identity with the various C. quinquefasciatus Estbetas. The gene is amplified in C. tritaeniorhynchus. Amplification of the same esterase in two independent species, along with multiple amplification events involving this esterase gene in C. quinquefasciatus suggests that the location of this gene within the genome predisposes it to amplification.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Cluster of paralogous genes
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