GEPHE SUMMARY
Entry Status
Published
GepheID
GP00000292
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Culex pipiens quinquefasciatus - sensitive S-LAB
Trait State in Taxon B
Culex pipiens quinquefasciatus- resistant Tem-R
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
southern house mosquito
Synonyms
Culex fatigans; Culex pipiens fatigans; Culex pipiens quinquefasciatus; southern house mosquito; Culex fatigan; Culex pipiens quiquefasciatus; Culex quinquifasciatus; Culex quinquifasiatus; Culex quiquefasciatus
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Culex pipiens quinquefasciatus - sensitive S-LAB
Taxon B
Common Name
southern house mosquito
Synonyms
Culex fatigans; Culex pipiens fatigans; Culex pipiens quinquefasciatus; southern house mosquito; Culex fatigan; Culex pipiens quiquefasciatus; Culex quinquifasciatus; Culex quinquifasiatus; Culex quiquefasciatus
Rank
species
Lineage
Show more ... lata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Culicinae; Culicini; Culex; Culex; Culex pipiens complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Culex pipiens quinquefasciatus- resistant Tem-R
GENOTYPIC CHANGE
Generic Gene Name
B1
Synonyms
-
String
-
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
Culex pipiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
Amplification of esterase B1 only
Experimental Evidence
Authors
Mouchès C; Pasteur N; Bergé JB; Hyrien O; Raymond M; de Saint Vincent BR; de Silvestri M; Georghiou GP
Abstract
An esterase gene from the mosquito Culex quinquefasciatus that is responsible for resistance to a variety of organophosphorus (OP) insecticides was cloned in lambda gt11 phage. This gene was used to investigate the genetic mechanism of the high production of the esterase B1 it encodes in OP-resistant Culex quinquefasciatus Say (Tem-R strain) from California. Adults of the Tem-R strain were found to possess at least 250 times more copies of the gene than adults of a susceptible strain (S-Lab). The finding that selection by pesticides may result in the amplification of genes encoding detoxifying enzymes in whole, normally developed, reproducing insects emphasizes the biological importance of this mechanism and opens new areas of investigation in pesticide resistance management.
RELATED GEPHE
Related Haplotypes
No matches found.
COMMENTS
Cluster of paralogous genes
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