GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00000296
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Lucilia sericata
Trait State in Taxon B
Lucilia sericata
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
common green bottle fly
Synonyms
Phaenicia sericata; common green bottle fly; sheep blowfly; Lucilia sericata (Meigen, 1826)
Rank
species
Lineage
Show more ... ; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Calyptratae; Oestroidea; Calliphoridae; Luciliinae; Lucilia
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
common green bottle fly
Synonyms
Phaenicia sericata; common green bottle fly; sheep blowfly; Lucilia sericata (Meigen, 1826)
Rank
species
Lineage
Show more ... ; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Calyptratae; Oestroidea; Calliphoridae; Luciliinae; Lucilia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
LcaE7
Synonyms
-
String
-
Sequence Similarities
Belongs to the type-B carboxylesterase/lipase family.
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
Lucilia cuprina
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Trp251Leu
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Hartley CJ; Newcomb RD; Russell RJ; Yong CG; Stevens JR; Yeates DK; La Salle J; Oakeshott JG
Abstract
Mutations of esterase 3 confer two forms of organophosphate resistance on contemporary Australasian Lucilia cuprina. One form, called diazinon resistance, is slightly more effective against commonly used insecticides and is now more prevalent than the other form, called malathion resistance. We report here that the single amino acid replacement associated with diazinon resistance and two replacements associated with malathion resistance also occur in esterase 3 in the sibling species Lucilia sericata, suggesting convergent evolution around a finite set of resistance options. We also find parallels between the species in the geographic distributions of the polymorphisms: In both cases, the diazinon-resistance change is absent or rare outside Australasia where insecticide pressure is lower, whereas the changes associated with malathion resistance are widespread. Furthermore, PCR analysis of pinned specimens of Australasian L. cuprina collected before the release of organophosphate insecticides reveals no cases of the diazinon-resistance change but several cases of those associated with malathion resistance. Thus, the early outbreak of resistance in this species can be explained by the preexistence of mutant alleles encoding malathion resistance. The pinned specimen analysis also shows much higher genetic diversity at the locus before organophosphate use, suggesting that the subsequent sweep of diazinon resistance in Australasia has compromised the scope for the locus to respond further to the ongoing challenge of the insecticides.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
2
COMMENTS
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