GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000308
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Canis familiaris
Trait State in Taxon B
Canis familiaris - Ridgeback
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
gray wolf
Synonyms
gray wolf; grey wolf; Canis lupus Linnaeus, 1758
Rank
species
Lineage
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rata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Parent
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
dog
Synonyms
Canis canis; Canis domesticus; Canis familiaris; dog; dogs; Canis familiaris Linnaeus, 1758; Canis lupus familiaris Linnaeus, 1758
Rank
subspecies
Lineage
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tomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis; Canis lupus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Canis familiaris - Ridgeback
GENOTYPIC CHANGE
Generic Gene Name
FGF4
Synonyms
-
String
Sequence Similarities
Belongs to the heparin-binding growth factors family.
GO - Molecular Function
GO:0008083 : growth factor activity
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GO - Biological Process
GO:0043066 : negative regulation of apoptotic process
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GO - Cellular Component
UniProtKB
Canis lupus familiaris
Canis lupus familiaris
GenebankID or UniProtKB
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Gene duplication
Experimental Evidence
Main Reference
Authors
Salmon Hillbertz NH; Isaksson M; Karlsson EK; Hellmén E; Pielberg GR; Savolainen P; Wade CM; von Euler H; et al.
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Abstract
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Cluster of paralogous genes
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