GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000312
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Cyprinus carpio - scaled
Trait State in Taxon B
Cyprinus carpio - "Mirror phenotype"
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
common carp
Synonyms
common carp; carp; fancy carp; koi; mirror carp; Cyprinus carpio Linnaeus, 1758; Cyprinus cyprio; Cyrpinus carpio
Rank
species
Lineage
Show more ... uteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidea; Cyprinidae; Cyprinus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
common carp
Synonyms
common carp; carp; fancy carp; koi; mirror carp; Cyprinus carpio Linnaeus, 1758; Cyprinus cyprio; Cyrpinus carpio
Rank
species
Lineage
Show more ... uteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes; Cyprinoidea; Cyprinidae; Cyprinus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
fgfr1a
Synonyms
cb231; fgfr1; FGFR-1-A; sb:cb231; bFGF-R-1-A; si:ch211-198o12.1
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
UniProtKB
Danio rerio
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
100-999 bp
Molecular Details of the Mutation
deletion of 310 bp
Experimental Evidence
Authors
Rohner N; Bercsényi M; Orbán L; Kolanczyk ME; Linke D; Brand M; Nüsslein-Volhard C; Harris MP
Abstract
The genetic basis of morphological variation both within and between species has been a lasting question in evolutionary biology and one of considerable recent debate. It is thought that changes in postembryonic development leading to variations in adult form often serve as a basis for selection . Thus, we investigated the genetic basis of the development of adult structures in the zebrafish via a forward genetic approach and asked whether the genes and mechanisms found could be predictive of changes in other species. Here we describe the spiegeldanio (spd) zebrafish mutation, which leads to reduced scale formation in the adult. The affected gene is fibroblast growth factor receptor 1 (fgfr1), which is known to have an essential embryonic function in vertebrate development. We find that the zebrafish has two paralogs encoding Fgfr1 and show that they function redundantly during embryogenesis. However, only one paralog is required for formation of scales during juvenile development. Furthermore, we identify loss-of-function alleles changing the coding sequence of Fgfr1a1 that have been independently selected twice during the domestication of the carp (Cyprinus carpio). These findings provide evidence for the role for gene duplication in providing the raw material for generation of morphological diversity.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
1
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